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Title:
SEPARATION AND PURIFICATION METHOD FOR HIGH-PURITY MOGROSIDE V
Document Type and Number:
WIPO Patent Application WO/2018/028144
Kind Code:
A1
Abstract:
The present application provides a separation and purification method for high-purity mogroside V, comprising the following steps: (1) dissolving and centrifuging: taking a Siraitia grosvenorii crude product, and adding water for dissolving and centrifuging to obtain centrifugal liquid; (2) ultrafiltering, nanofiltering, and concentrating: ultrafiltering, nanofiltering, and concentrating in vacuum the centrifugal liquid to obtain a concentrated solution; (3) mixing with silica gel, eluting, and concentrating: mixing the concentrated solution with silica gel, drying, loading into a silica gel chromatography column, eluting, collecting target fractions in a segmented manner, concentrating, and drying to obtain mogroside V dry powder; and (4) crystallizing, washing, and drying: dissolving the mogroside V dry powder, filtering, crystallizing, and washing and drying a crystal to obtain a high-purity mogroside V product. The purity of the high-purity mogroside V product obtained by the method of the present invention is greater than or equal to 98.4%, and the final yield of the high-purity mogroside V product is greater than 90%. The method of the present invention breaks limitations of the prior art, simplifies the technological process, features high operability, safety, environmental protection and low costs, and is suitable for industrial production.

Inventors:
LONG, Weian (No.8, Xingkang South Rd. High-Tech Zon, Changsha Hunan 5, 410205, CN)
HUANG, Huaxue (No.8, Xingkang South Rd. High-Tech Zon, Changsha Hunan 5, 410205, CN)
Application Number:
CN2017/070142
Publication Date:
February 15, 2018
Filing Date:
January 04, 2017
Export Citation:
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Assignee:
HUNAN HUACHENG BIOTECH INC (No.8, Xingkang South Rd. High-Tech Zon, Changsha Hunan 5, 410205, CN)
International Classes:
C07J17/00
Foreign References:
CN106008645A2016-10-12
CN104892717A2015-09-09
CN104086614A2014-10-08
CN1436786A2003-08-20
Attorney, Agent or Firm:
CHINABLE IP (620 Room, 35-10-2 the 6th floor,No.35 Anding Road,Chaoyang District, Beijing 9, 100029, CN)
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