Title:
SEPARATION AND PURIFICATION METHOD FOR URIDINE TRIPHOSPHATE
Document Type and Number:
WIPO Patent Application WO/2020/103916
Kind Code:
A1
Abstract:
Provided is a separation and purification method for uridine triphosphate. The separation and purification method comprises the following steps: 1) loading: filtering crude uridine triphosphate and then loading same into a chromatography column, wherein the packing of the chromatography column is monodisperse microspheres with polyacrylate as a matrix; 2) eluting: eluting UTP adsorbed in the chromatography column with an eluate; and 3) collecting and gathering: collecting the eluted uridine triphosphate solution in sections, and gathering component solutions that meet the target peak requirements. The separation and purification method for uridine triphosphate of the present invention is simple and convenient, has a short purification cycle, and can satisfy the high purity requirement of uridine triphosphate by means of only one step of chromatography purification. The uridine triphosphate has a purity of 99.9% or more and a high and stable purification yield.
Inventors:
JIANG BIWANG JACK (CN)
SHI LINGCHAO (CN)
ZOU SHENG (CN)
ZHANG YANHUI (CN)
SHI LINGCHAO (CN)
ZOU SHENG (CN)
ZHANG YANHUI (CN)
Application Number:
PCT/CN2019/120049
Publication Date:
May 28, 2020
Filing Date:
November 21, 2019
Export Citation:
Assignee:
SUZHOU NANOMICRO TECH COMPANY LIMITED (CN)
International Classes:
C07H1/06; C07H19/10
Foreign References:
| CN107868120A | 2018-04-03 | |||
| CN109503687A | 2019-03-22 | |||
| US3509128A | 1970-04-28 |
Other References:
RUAN, WENHUI ET AL.: "Thermodynamics and Kinetics of the Adsorption of UTP onto the DuoliteA-30 Resin", ION EXCHANGE AND ADSORPTION, no. 4, 20 August 2008 (2008-08-20)
Attorney, Agent or Firm:
ADVANCE CHINA IP LAW OFFICE (CN)
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