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Title:
SEPARATION AND PURIFICATION METHOD FOR VANCOMYCIN HYDROCHLORIDE OF HIGH PURITY
Document Type and Number:
WIPO Patent Application WO/2015/062168
Kind Code:
A1
Abstract:
Provided is a separation and purification method for vancomycin hydrochloride of a high purity. The method comprises the following steps: (1) obtaining a vancomycin hydrochloride solution from a crude vancomycin product by ion exchange chromatography and obtaining a concentrate by nanofiltration desalination and concentration; (2) adjusting the concentrate with a hydrochloric acid solution and then performing a column chromatography using a reverse chromatography column for the adjusted concentrate; (3) collecting the chromatographic solution of vancomycin to obtain a mixed chromatographic solution; (4) adjusting the mixed chromatographic solution, and separating the solution and the salts by nanofiltration desalination and concentration to obtain a concentrate; and (5) obtaining a vancomycin dry powder with a chromatographic purity of up to 99% and a pure white appearance by dehydrating and drying the concentrate of step (4), or by solvent crystallization or salting-out crystallization.

Inventors:
LI ENMIN (CN)
ZHUANG YIYUN (CN)
WANG JUE (CN)
SUN XINQIANG (CN)
LAO XUEJUN (CN)
JIANG BIWANG (CN)
Application Number:
PCT/CN2014/000950
Publication Date:
May 07, 2015
Filing Date:
October 27, 2014
Export Citation:
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Assignee:
ZHEJIANG MED XINCHANG PHARM (CN)
International Classes:
A61K38/14; C07K1/22; C07K9/00
Domestic Patent References:
WO2006061166A12006-06-15
WO2006061166A12006-06-15
Foreign References:
CN101456903A2009-06-17
CN101440127A2009-05-27
CN200710187300A2007-11-19
CN01132048A2001-10-30
CN200710198599A2007-12-14
Other References:
See also references of EP 3064214A4
Attorney, Agent or Firm:
FAITHFULAW INTERNATIONAL IP LAW OFFICE (CN)
北京乾诚五洲知识产权代理有限责任公司 (CN)
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