Title:
SEQUENCE ANALYZING METHOD, SEQUENCE ANALYZING DEVICE, POLYMERIZATION CONDITION PROPOSING DEVICE, AND AUTOMATIC SYNTHESIZING DEVICE
Document Type and Number:
WIPO Patent Application WO/2024/018725
Kind Code:
A1
Abstract:
Provided is a simple sequence analyzing method for macromolecules, for estimating the content, in a polymer, of polyads configured from an arrangement of a plurality of units, the method including: determining a number K of polyad variants; successively ionizing gas components generated by heating each of a reference sample and an estimation target sample, to obtain a data matrix including a two-dimensional mass spectrum; performing nonnegative matrix factorization of the data matrix to decompose the data matrix into a product of a basis spectra matrix and an intensity distribution matrix; performing nonnegative matrix factorization of the intensity distribution matrix to decompose the intensity distribution matrix into a product of a matrix representing mass fractions of model polymers consisting only of polyads and a matrix representing feature vectors; setting a K-1 dimensional simple substance encompassing all the feature vectors of the sample, with the feature vectors of the model polymers as end members; and estimating a content ratio of each polyad from a ratio of distances between the end members and the feature vectors of the estimation target sample.
Inventors:
NAITO MASANOBU (JP)
HIBI YUSUKE (JP)
HIBI YUSUKE (JP)
Application Number:
PCT/JP2023/017129
Publication Date:
January 25, 2024
Filing Date:
May 02, 2023
Export Citation:
Assignee:
NAT INST MATERIALS SCIENCE (JP)
International Classes:
G01N27/62
Domestic Patent References:
| WO2019208225A1 | 2019-10-31 |
Foreign References:
| US20130035867A1 | 2013-02-07 | |||
| JP2018512580A | 2018-05-17 |
Attorney, Agent or Firm:
SPRING IP (JP)
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