Title:
SEQUENCE OF STRUCTURALLY SENSITIVE POLYPEPTIDE ANTIGEN OF VON WILLEBRAND FACTOR
Document Type and Number:
WIPO Patent Application WO/2021/056609
Kind Code:
A1
Abstract:
Disclosed are a sequence of a polypeptide antigen, the spatially sensitive position of the polypeptide antigen in human von Willebrand factor and the use of the polypeptide antigen in the preparation of a preparation for diagnosing and/or treating diseases associated with von Willebrand factor. The polypeptide antigen comprises the amino acid sequence shown in SEQ ID No. 1, a biologically active fragment, or a variant thereof. The spatial position of the polypeptide is changed from non-solvent exposure to solvent exposure when von Willebrand factor is in an active state, so that the polypeptide can be recognized by an antibody. An antibody for recognizing active-state von Willebrand factor and prepared by using the polypeptide antigen can be used for diagnosing and treating various diseases associated with von Willebrand factor.
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Inventors:
DENG WEI (CN)
Application Number:
PCT/CN2019/110564
Publication Date:
April 01, 2021
Filing Date:
October 11, 2019
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
A61K39/00; A61K39/395; A61P7/04; C07K14/755; C07K16/36; G01N33/68; G01N33/86
Foreign References:
| CN110624105A | 2019-12-31 | |||
| CN110063935A | 2019-07-30 | |||
| CN108997501A | 2018-12-14 |
Other References:
JIA QIAN, HE YANG, RUAN CHANG-GENG: "Research Advances of Acquired Thrombotic Thrombocytopenic Purpura", ZHONGGUO SHIYAN XUEYEXUE ZAZHI - JOURNAL OF EXPERIMENTALHEMATOLOGY, ZHONGGUO SHIYAN, XUEYEXUE ZAZHISHE, BEIJING, CN, vol. 26, no. 4, 1 August 2018 (2018-08-01), CN, pages 1230 - 1234, XP055794446, ISSN: 1009-2137, DOI: 10.7534/j.issn.1009-2137.2018.04.048
F. CALLEWAERT, J. ROODT, H. ULRICHTS, T. STOHR, W. J. VAN RENSBURG, S. LAMPRECHT, S. ROSSENU, S. PRIEM, W. WILLEMS, J.-B. HOLZ: "Evaluation of efficacy and safety of the anti-VWF Nanobody ALX-0681 in a preclinical baboon model of acquired thrombotic thrombocytopenic purpura", BLOOD, vol. 120, no. 17, 25 October 2012 (2012-10-25), pages 3603 - 3610, XP055109473, ISSN: 00064971, DOI: 10.1182/blood-2012-04-420943
DENG W., WANG Y., DRUZAK S. A., HEALEY J. F., SYED A. K., LOLLAR P., LI R.: "A discontinuous autoinhibitory module masks the A1 domain of von Willebrand factor", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, BLACKWELL PUBLISHING, OXFORD, GB, vol. 15, no. 9, 1 September 2017 (2017-09-01), GB, pages 1867 - 1877, XP055794443, ISSN: 1538-7933, DOI: 10.1111/jth.13775
F. CALLEWAERT, J. ROODT, H. ULRICHTS, T. STOHR, W. J. VAN RENSBURG, S. LAMPRECHT, S. ROSSENU, S. PRIEM, W. WILLEMS, J.-B. HOLZ: "Evaluation of efficacy and safety of the anti-VWF Nanobody ALX-0681 in a preclinical baboon model of acquired thrombotic thrombocytopenic purpura", BLOOD, vol. 120, no. 17, 25 October 2012 (2012-10-25), pages 3603 - 3610, XP055109473, ISSN: 00064971, DOI: 10.1182/blood-2012-04-420943
DENG W., WANG Y., DRUZAK S. A., HEALEY J. F., SYED A. K., LOLLAR P., LI R.: "A discontinuous autoinhibitory module masks the A1 domain of von Willebrand factor", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, BLACKWELL PUBLISHING, OXFORD, GB, vol. 15, no. 9, 1 September 2017 (2017-09-01), GB, pages 1867 - 1877, XP055794443, ISSN: 1538-7933, DOI: 10.1111/jth.13775
Attorney, Agent or Firm:
CENTRAL SOUTH WELL INTELLECTUAL PROPERTY OFFICE (CN)
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