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Title:
A SERIES OF CATALYSTS FOR THE HYPERPOLARISATION OF SUBSTRATES
Document Type and Number:
WIPO Patent Application WO/2020/095047
Kind Code:
A3
Abstract:
There is described a method for the preparation of a hyperpolarised agent, wherein said agent comprises at least one –N-, –O- or –S- moiety (optionally protonated) and a secondary binding site; said method comprising: (i) preparing a fluid containing a polarisation transfer precatalyst and parahydrogen; (ii) introducing a co-ligand to interact with the transfer precatalyst to form a polarisation transfer catalyst; (iii) applying a magnetic field or radio frequency excitation to (ii), such that hyperpolarisation is transferred from parahydrogen to a target molecule; (iv) introducing a target molecule containing at least at least one –N-, –O- or –S- moiety, in conjunction with a secondary binding to form a hyperpolarised agent; wherein the co-ligand is selected from the group consisting of one or more of a sulfoxide, a thioester, a phosphine, an amine, CO, an isonitrile and a nitrogen heterocycle.

Inventors:
ROY SOUMYA SINGHA (GB)
IALI WISSAM (GB)
TICKNER BEN (GB)
DUCKETT SIMON BENEDICT (GB)
Application Number:
PCT/GB2019/053146
Publication Date:
August 20, 2020
Filing Date:
November 06, 2019
Export Citation:
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Assignee:
UNIV YORK (GB)
International Classes:
G01R33/28; G01N24/08; G01N33/58
Other References:
WISSAM IALI ET AL: "Direct and indirect hyperpolarisation of amines using para hydrogen", CHEMICAL SCIENCE, vol. 9, no. 15, 9 March 2018 (2018-03-09), United Kingdom, pages 3677 - 3684, XP055539052, ISSN: 2041-6520, DOI: 10.1039/C8SC00526E
"ANNUAL REPORTS ON NMR SPECTROSCOPY", vol. 93, 10 November 2017, LONDON, GB, ISSN: 0066-4103, article THOMAS B.R. ROBERTSON ET AL: "Perspective on the Hyperpolarisation Technique Signal Amplification by Reversible Exchange (SABRE) in NMR Spectroscopy and MR Imaging", pages: 145 - 212, XP055542637, DOI: 10.1016/bs.arnmr.2017.08.001
FERNANDEZ DIAZ-RULLO FERNANDO ET AL: "Synthesis and hyperpolarisation of eNOS substrates for quantification of NO production by1H NMR spectroscopy", BIOORGANIC & MEDICINAL CHEMISTRY : A TETRAHEDRON PUBLICATION FOR THE RAPID DISSEMINATION OF FULL ORIGINAL RESEARCH PAPERS AND CRITICAL REVIEWS ON BIOMOLECULAR CHEMISTRY, MEDICINAL CHEMISTRY AND RELATED DISCIPLINES, ELSEVIER, NL, vol. 25, no. 10, 21 March 2017 (2017-03-21), pages 2730 - 2742, XP029978681, ISSN: 0968-0896, DOI: 10.1016/J.BMC.2017.03.041
M. FEKETE ET AL: "Utilisation of water soluble iridium catalysts for signal amplification by reversible exchange", DALTON TRANSACTIONS, vol. 44, no. 17, 1 January 2015 (2015-01-01), pages 7870 - 7880, XP055663813, ISSN: 1477-9226, DOI: 10.1039/C5DT00311C
BEN. J. TICKNER ET AL: "Mechanistic insight into novel sulfoxide containing SABRE polarisation transfer catalysts", DALTON TRANSACTIONS, vol. 48, no. 40, 24 September 2019 (2019-09-24), pages 15198 - 15206, XP055663817, ISSN: 1477-9226, DOI: 10.1039/C9DT02951F
Attorney, Agent or Firm:
GILHOLM, Stephen Philip (GB)
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