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Patent Searching and Data


Title:
SERINE PROTEASE INHIBITOR KAZAL (SPIK) COMPOSITIONS AND METHODS
Document Type and Number:
WIPO Patent Application WO/2019/173503
Kind Code:
A3
Abstract:
Anti-AS-SPIK antibodies are disclosed, along with methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to diagnose disorders characterized by the expression of AS-SPIK (e.g., liver cancer). Diagnostic methods and kits comprising the anti-AS-SPIK antibodies are also disclosed.

Inventors:
LU XUANYONG (US)
LU FELIX (US)
Application Number:
PCT/US2019/020999
Publication Date:
October 17, 2019
Filing Date:
March 06, 2019
Export Citation:
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Assignee:
IMCARE BIOTECH LLC (US)
International Classes:
C07K16/30; A61P35/00; C07K16/38; G01N33/53
Domestic Patent References:
WO2011102999A22011-08-25
Foreign References:
US20140308657A12014-10-16
US20130280255A12013-10-24
Other References:
B. ATEEQ ET AL: "Therapeutic Targeting of SPINK1-Positive Prostate Cancer", SCIENCE TRANSLATIONAL MEDICINE, vol. 3, no. 72, 2 March 2011 (2011-03-02), US, pages 72ra17 - 72ra17, XP055606823, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.3001498
WENDY WEIJIA SOON ET AL: "Combined genomic and phenotype screening reveals secretory factor SPINK1 as an invasion and survival factor associated with patient prognosis in breast cancer", EMBO MOLECULAR MEDICINE, vol. 3, no. 8, 1 August 2011 (2011-08-01), pages 451 - 464, XP055045645, ISSN: 1757-4676, DOI: 10.1002/emmm.201100150
V GOUYER ET AL: "Autocrine induction of invasion and metastasis by tumor-associated trypsin inhibitor in human colon cancer cells", ONCOGENE, vol. 27, no. 29, 3 March 2008 (2008-03-03), London, pages 4024 - 4033, XP055606841, ISSN: 0950-9232, DOI: 10.1038/onc.2008.42
K. RASANEN ET AL: "Emerging Roles of SPINK1 in Cancer", CLINICAL CHEMISTRY, vol. 62, no. 3, 11 December 2015 (2015-12-11), pages 449 - 457, XP055606942, ISSN: 0009-9147, DOI: 10.1373/clinchem.2015.241513
Attorney, Agent or Firm:
PELLETIER, Benjamin C. et al. (US)
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