SEROTONIN 5-HT3 RECEPTOR AGONIST - RES FOUND ITSUU LAB

Title:

SEROTONIN 5-HT3 RECEPTOR AGONIST

Document Type and Number:

WIPO Patent Application WO/2006/028161

Kind Code:

A1

Abstract:

Disclosed is a serotonin 5-HT3 receptor agonist which contains a compound represented by the general formula (1) below or a physiologically acceptable salt thereof as an active constituent and has both serotonin 5-HT3 receptor antagonizing effect and serotonin 5-HT3 receptor activating effect. (1) (In the formula, R¹, R³ and R⁵ respectively represent a hydrogen atom, a lower alkyl group, a lower alkenyl group, a halogen atom, a hydroxyl group, an amino group, a lower alkoxy group, a carboxyl group, a carbamoyl group or a nitro group; R² and R⁴ respectively represent a halogen atom, a hydroxyl group or an amino group; R⁶ represents a hydrogen atom, a lower alkyl group or a lower alkenyl group; R⁷ represents a hydrogen atom, a lower alkyl group, a lower alkenyl group or aralkyl group; and m and n respectively represent an integer of 1-3.)

Inventors:

JIKYO TAMAKI (JP)
SHUDO KOICHI (JP)

Application Number:

PCT/JP2005/016489

Publication Date:

March 16, 2006

Filing Date:

September 08, 2005

Export Citation:

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Assignee:

RES FOUND ITSUU LAB (JP)
JIKYO TAMAKI (JP)
SHUDO KOICHI (JP)

International Classes:

C07D295/20; A61K31/395; A61K31/495; A61K31/551; A61P1/08; A61P1/10; A61P1/12; A61P43/00; C07D243/08

Domestic Patent References:

WO1998031677A1	1998-07-23
WO2003066595A2	2003-08-14

Foreign References:

JPH1029987A	1998-02-03
JPH06345744A	1994-12-20
JP2000505795A	2000-05-16
JPS53135945A	1978-11-28
US20040006091A1	2004-01-08

Other References: