Title:
SERTRALINE HYDROCHLORIDE POLYMORPHS
Document Type and Number:
WIPO Patent Application WO2000032551
Kind Code:
A9
Abstract:
The present invention is directed to forms II, III, V, VI, VII, VIII, IX and X of sertraline hydrochloride and novel methods for their preparation. According to the present invention, sertraline hydrochloride polymorph II may be produced by slurrying sertraline hydrochloride polymorph VI in aprotic organic solvent. Sertraline hydrochloride polymorphic form III may be produced by heating sertraline hydrochloride polymorphs V and VI. Sertraline hydrochloride forms V and VI may be produced from either sertraline hydrochloride or sertraline base by crystallization. Sertraline hydrochloride Form VII may be produced by suspending sertraline chloride polymorph V in water, followed by filtration. Sertraline hydrochloride Forms VIII and IX may be produced by suspending sertraline base in water followed by acidification and filtration. Sertraline hydrochloride Form X and be produced by suspending sertraline hydrochloride in benzyl alcohol with heating, followed by filtration.
Inventors:
SCHWARTZ EDUARD (IL)
NIDAM TAMAR (IL)
LIBERMAN ANITA (IL)
MENDELOVICI MARIOARA (IL)
ARONHIME JEHUDIT (IL)
SINGER CLAUDE (IL)
VALDMAN EVGENI (IL)
NIDAM TAMAR (IL)
LIBERMAN ANITA (IL)
MENDELOVICI MARIOARA (IL)
ARONHIME JEHUDIT (IL)
SINGER CLAUDE (IL)
VALDMAN EVGENI (IL)
Application Number:
PCT/US1999/027881
Publication Date:
July 19, 2001
Filing Date:
November 24, 1999
Export Citation:
Assignee:
TEVA PHARMA (US)
TEVA PHARMA (US)
SCHWARTZ EDUARD (IL)
NIDAM TAMAR (IL)
LIBERMAN ANITA (IL)
MENDELOVICI MARIOARA (IL)
ARONHIME JEHUDIT (IL)
SINGER CLAUDE (IL)
VALDMAN EVGENI (IL)
TEVA PHARMA (US)
SCHWARTZ EDUARD (IL)
NIDAM TAMAR (IL)
LIBERMAN ANITA (IL)
MENDELOVICI MARIOARA (IL)
ARONHIME JEHUDIT (IL)
SINGER CLAUDE (IL)
VALDMAN EVGENI (IL)
International Classes:
A61K31/137; A61P25/22; A61P25/24; C07C209/84; C07C209/90; C07C211/42; (IPC1-7): C07C211/00
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