Title:
SEVEN-MEMBERED RING COMPOUND AND PHARMACEUTICAL USE THEREFOR
Document Type and Number:
WIPO Patent Application WO/2011/078413
Kind Code:
A1
Abstract:
Provided is a compound that has a nitrogen-containing seven-membered ring skeleton represented by formula (I) and is useful in the prevention or treatment of pathological conditions in which chymase is involved. Also provided is a drug, containing the aforementioned compound, for prevention or treatment of disorders in which chymase is involved.
Inventors:
MUTO TSUYOSHI (JP)
TANAKA TAISAKU (JP)
FUTAMURA JUNKO (JP)
IMAJO SEICHI (JP)
SUGAWARA HAJIME (JP)
TANAKA TAISAKU (JP)
FUTAMURA JUNKO (JP)
IMAJO SEICHI (JP)
SUGAWARA HAJIME (JP)
Application Number:
PCT/JP2010/073879
Publication Date:
June 30, 2011
Filing Date:
December 24, 2010
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
MUTO TSUYOSHI (JP)
TANAKA TAISAKU (JP)
FUTAMURA JUNKO (JP)
IMAJO SEICHI (JP)
SUGAWARA HAJIME (JP)
MUTO TSUYOSHI (JP)
TANAKA TAISAKU (JP)
FUTAMURA JUNKO (JP)
IMAJO SEICHI (JP)
SUGAWARA HAJIME (JP)
International Classes:
C07D243/08; A61K31/551; A61P1/04; A61P3/10; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/12; A61P17/12; A61P19/02; A61P27/02; A61P27/06; A61P27/16; A61P29/00; A61P35/00; A61P37/08; A61P43/00; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D413/12; C07D487/04; C07D498/04
Foreign References:
| US20090111796A1 | 2009-04-30 | |||
| EP2025672A1 | 2009-02-18 |
Other References:
MARUOKA, H. ET AL.: "Development of 6-benzyl- substituted 4-aminocarbonyl-1,4-diazepane-2,5- diones as orally active human chymase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, no. 12, 2007, pages 3435 - 3439, XP022097799
TANAKA, T. ET AL.: "Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5- diones as a novel scaffold for human chymase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, no. 12, 2007, pages 3431 - 3434, XP022097798
TSUYOSHI MUTO ET AL.: "4-sulfonyl-1,4-diazepane- 2,5-diones Kokkaku o Yusuru Shinki Chymase Sogaizai no Gosei to Kozo Kassei Sokan", ABSTRACTS OF SYMPOSIUM ON MEDICINAL CHEMISTRY, vol. 26, 2007, pages 208 - 209, XP008167353
TSUYOSHI MUTO ET AL.: "4-aminocarbonyl-1,4- diazepane-2,5-diones Kokkaku o Yusuru Keiko Chymase Sogaizai no Sosei", ABSTRACTS OF SYMPOSIUM ON MEDICINAL CHEMISTRY, vol. 26, 2007, pages 210 - 211, XP008167354
See also references of EP 2518056A4
TANAKA, T. ET AL.: "Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5- diones as a novel scaffold for human chymase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, no. 12, 2007, pages 3431 - 3434, XP022097798
TSUYOSHI MUTO ET AL.: "4-sulfonyl-1,4-diazepane- 2,5-diones Kokkaku o Yusuru Shinki Chymase Sogaizai no Gosei to Kozo Kassei Sokan", ABSTRACTS OF SYMPOSIUM ON MEDICINAL CHEMISTRY, vol. 26, 2007, pages 208 - 209, XP008167353
TSUYOSHI MUTO ET AL.: "4-aminocarbonyl-1,4- diazepane-2,5-diones Kokkaku o Yusuru Keiko Chymase Sogaizai no Sosei", ABSTRACTS OF SYMPOSIUM ON MEDICINAL CHEMISTRY, vol. 26, 2007, pages 210 - 211, XP008167354
See also references of EP 2518056A4
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
Aoki 篤 (JP)
Aoki 篤 (JP)
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