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Title:
THE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS
Document Type and Number:
WIPO Patent Application WO2004092360
Kind Code:
A3
Abstract:
An outbreak of a virulent respiratory virus, now known as Severe Acute Respiratory Syndrome (SARS), was identified in Hong Kong, China and a growing number of countries around the world in 2003. The invention relates to nucleic acids and proteins from the SARS coronavirus. These nucleic acids and proteins can be used in the preparation and manufacture of vaccine formulations, diagnostic reagents, kits, etc. The invention also provides methods for treating SARS by administering small molecule antiviral compounds, as well as methods of identifying potent small molecules for the treatment of SARS.

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Inventors:
RAPPUOLI RINO (IT)
MASIGNANI VEGA (IT)
STADLER KONRAD (DE)
GREGERSEN JENS-PETER (DE)
CHIEN DAVID (US)
HAN JANG (US)
POLO JOHN (US)
WEINER AMY (US)
HOUGHTON MICHAEL (US)
SONG HYUN CHUL (US)
SEO MI YOUNG (US)
DONNELLY JOHN J (US)
KLENK HANS DIETER (DE)
VALIANTE NICHOLAS (US)
Application Number:
PCT/US2004/011710
Publication Date:
August 04, 2005
Filing Date:
April 09, 2004
Export Citation:
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Assignee:
CHIRON CORP (US)
RAPPUOLI RINO (IT)
MASIGNANI VEGA (IT)
STADLER KONRAD (DE)
GREGERSEN JENS-PETER (DE)
CHIEN DAVID (US)
HAN JANG (US)
POLO JOHN (US)
WEINER AMY (US)
HOUGHTON MICHAEL (US)
SONG HYUN CHUL (US)
SEO MI YOUNG (US)
DONNELLY JOHN J (US)
KLENK HANS DIETER (DE)
VALIANTE NICHOLAS (US)
International Classes:
A61K35/76; A61K38/16; A61K39/215; C07K14/165; C07K16/10; C12N7/06; C12Q1/70; A61K39/00; (IPC1-7): C07K14/165; C12Q1/70; C07K16/10; A61K35/76; A61K38/16
Domestic Patent References:
WO2004091524A22004-10-28
WO2004085650A12004-10-07
WO2004085633A12004-10-07
WO2004085455A12004-10-07
WO2004096842A22004-11-11
WO2004092208A22004-10-28
Other References:
PEIRIS J S M ET AL: "Coronavirus as a possible cause of severe acute respiratory syndrome.", LANCET. 19 APR 2003, vol. 361, no. 9366, 8 April 2003 (2003-04-08), pages 1319 - 1325, XP004421148, ISSN: 0140-6736
DROSTEN CHRISTIAN ET AL: "Identification of a novel coronavirus in patients with severe acute respiratory syndrome.", NEW ENGLAND JOURNAL OF MEDICINE, vol. 348, no. 20, 10 April 2003 (2003-04-10), pages 1967 - 1976, XP002305233, ISSN: 0028-4793
DATABASE GENBANK [online] NATIONAL CENTER FOR BIO; 14 April 2003 (2003-04-14), BCCA GENOME SCIENCES CENTER BRITISH COLUMBIA: "SARS coronavirus Tor2", XP002319430, retrieved from NCBI Database accession no. AY274119
ROTA PAUL A ET AL: "Characterization of a novel coronavirus associated with severe acute respiratory syndrome", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 300, no. 5624, 30 May 2003 (2003-05-30), pages 1394 - 1399, XP002288938, ISSN: 0036-8075
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