Title:
SEX STEROID ACTIVITY INHIBITORS
Document Type and Number:
WIPO Patent Application WO1993010741
Kind Code:
A3
Abstract:
Inhibitors of sex steroid activity, for example those having the general structure may be used as part of a pharmaceutical composition to provide antiestrogenic effects and/or to suppress estrogen synthesis. Such pharmaceutical compositions are useful for the treatment of breast cancer or other diseases whose progress is aided by activation of sex steroid receptors.
Inventors:
LABRIE FERNAND (CA)
MERAND YVES (CA)
MERAND YVES (CA)
Application Number:
PCT/CA1992/000518
Publication Date:
February 03, 1994
Filing Date:
December 01, 1992
Export Citation:
Assignee:
ENDORECHERCHE INC (CA)
International Classes:
A61K31/10; C07D295/08; A61K31/135; A61K31/138; A61K31/165; A61K31/35; A61K31/352; A61K31/38; A61K31/382; A61K31/40; A61K31/4025; A61K31/403; A61K31/404; A61K31/435; A61K31/445; A61K31/4453; A61K31/452; A61K31/4523; A61K31/453; A61K31/4535; A61K31/47; A61K31/4709; A61K31/472; A61K31/4725; A61K31/535; A61K31/5375; A61K31/565; A61K31/57; A61P5/28; A61P5/32; A61P15/16; A61P17/08; A61P17/14; A61P35/00; C07C215/64; C07C217/18; C07C235/34; C07C235/40; C07C317/10; C07C317/18; C07D209/08; C07D209/12; C07D215/06; C07D215/14; C07D215/20; C07D217/04; C07D217/16; C07D235/18; C07D295/084; C07D295/092; C07D295/096; C07D295/185; C07D311/02; C07D311/04; C07D311/60; C07D335/06; C07D335/08; C07D401/06; C07D401/12; C07D405/06; C07D405/12; C07D413/12; C07J1/00; C07J17/00; C07J21/00; C07J41/00; C07J51/00; C07J53/00; C07J71/00; (IPC1-7): A61K/
Domestic Patent References:
| WO1990010462A1 | 1990-09-20 |
Foreign References:
| EP0367576A2 | 1990-05-09 | |||
| EP0124369A1 | 1984-11-07 | |||
| US3396169A | 1968-08-06 | |||
| EP0138504A2 | 1985-04-24 | |||
| EP0470310A1 | 1992-02-12 | |||
| US3471520A | 1969-10-07 | |||
| US3321483A | 1967-05-23 | |||
| US3597431A | 1971-08-03 |
Other References:
C.D. JONES ET AL.: "SYNTHESIS AND ANTIESTROGENIC ACTIVITY OF (3,4-DIHYDRO-2-(4-METHOXYPHENYL)-1-NAPHTHALENYL)(4-(2-(1PYRROLIDINYL)ETHOXY)-PHENYL)METHANONE, METHANESULFONIC ACID SALT", JOURNAL OF MEDICINAL CHEMISTRY, vol. 22, no. 8, 1979, pages 962 - 966
A.P. SHARMA ET AL.: "STRUCTURE-ACTIVITY RELATIONSHIP OF ANTIESTROGENS", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 12, 1990, pages 3216 - 3222
A.P. SHARMA ET AL.: "STRUCTURE-ACTIVITY RELATIONSHIP OF ANTIESTROGENS", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 12, 1990, pages 3222 - 3229
A. SAEED ET AL.: "STRUCTURE-ACTIVITY RELATIONSHIP OF ANTIESTROGENS", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 12, 1990, pages 3210 - 3216
J.D. DHAR ET AL.: "BIOLOGICAL PROFILE OF 2-(4-(2-N-PIPERIDINOETHOXY)PHENYL)-3-PHENYL (2H) BENZO (B) PYRAN-A POTENT ANTIIMPLANTATION AGENT IN RAT", CONTRACEPTION, vol. 44, no. 4, October 1991 (1991-10-01), pages 461 - 472
S. STOESSEL ET AL.: "COMPETITIVE BINDING ASSAY FOR ESTROGEN RECEPTOR IN MONOLAYER CULTURE: MEASURE OF RECEPTOR ACTIVATION POTENCY", THE JOURNAL OF STEROID BIOCHEMISTRY, vol. 25, no. 5A, 1986, pages 677 - 682
E. VON ANGERER ET AL.: "1-(AMINOALKYL)-2-PHENYLINDOLES AS NOVEL PURE ESTROGEN ANTAGONISTS", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 9, 1990, pages 2635 - 2640
R.R. CRENSHAW ET AL.: "POTENTIAL ANTIFERTILITY AGENTS", JOURNAL OF MEDICINAL CHEMISTRY, vol. 14, no. 12, 1971, pages 1185 - 1190
V.L. PRUITT ET AL.: "SYNTHESIS OF SOME 3,4-DIHYDRO-2H-1-BENZOTHIOPYRAN-4-OLS", ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, vol. 22, no. 2, 1990, pages 235 - 244
A.P. SHARMA ET AL.: "STRUCTURE-ACTIVITY RELATIONSHIP OF ANTIESTROGENS", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 12, 1990, pages 3216 - 3222
A.P. SHARMA ET AL.: "STRUCTURE-ACTIVITY RELATIONSHIP OF ANTIESTROGENS", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 12, 1990, pages 3222 - 3229
A. SAEED ET AL.: "STRUCTURE-ACTIVITY RELATIONSHIP OF ANTIESTROGENS", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 12, 1990, pages 3210 - 3216
J.D. DHAR ET AL.: "BIOLOGICAL PROFILE OF 2-(4-(2-N-PIPERIDINOETHOXY)PHENYL)-3-PHENYL (2H) BENZO (B) PYRAN-A POTENT ANTIIMPLANTATION AGENT IN RAT", CONTRACEPTION, vol. 44, no. 4, October 1991 (1991-10-01), pages 461 - 472
S. STOESSEL ET AL.: "COMPETITIVE BINDING ASSAY FOR ESTROGEN RECEPTOR IN MONOLAYER CULTURE: MEASURE OF RECEPTOR ACTIVATION POTENCY", THE JOURNAL OF STEROID BIOCHEMISTRY, vol. 25, no. 5A, 1986, pages 677 - 682
E. VON ANGERER ET AL.: "1-(AMINOALKYL)-2-PHENYLINDOLES AS NOVEL PURE ESTROGEN ANTAGONISTS", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 9, 1990, pages 2635 - 2640
R.R. CRENSHAW ET AL.: "POTENTIAL ANTIFERTILITY AGENTS", JOURNAL OF MEDICINAL CHEMISTRY, vol. 14, no. 12, 1971, pages 1185 - 1190
V.L. PRUITT ET AL.: "SYNTHESIS OF SOME 3,4-DIHYDRO-2H-1-BENZOTHIOPYRAN-4-OLS", ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, vol. 22, no. 2, 1990, pages 235 - 244
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