Title:
SGRF GENETICALLY MODIFIED NONHUMAN ANIMAL
Document Type and Number:
WIPO Patent Application WO/2003/034818
Kind Code:
A1
Abstract:
A chimeric mouse is obtained by substituting the exon part of SGRF gene by an appropriate drug marker gene to thereby construct a targeting vector and then transferring this vector into a mouse ES cell line. This chimeric mouse is mated with a C57BL&sol 6J mouse to give mice comprising cells wherein one of the SGRF gene pair has been inactivated. Further, these mice are mated together to thereby successfully construct a mouse wherein both genes of the SGRF gene pair have been inactivated. This genetically modified animal is usable in, for example, presuming side effects of an SGRF antagonist, etc.
Inventors:
HABU KIYOSHI (JP)
HIRATA YUICHI (JP)
HIRATA YUICHI (JP)
Application Number:
PCT/JP2002/011047
Publication Date:
May 01, 2003
Filing Date:
October 24, 2002
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
HABU KIYOSHI (JP)
HIRATA YUICHI (JP)
HABU KIYOSHI (JP)
HIRATA YUICHI (JP)
International Classes:
A01K67/027; C12N15/85; (IPC1-7): A01K67/027; C12N15/09; C12N5/10
Domestic Patent References:
| WO1999054357A1 | 1999-10-28 |
Other References:
TOSHIYUKI TAKAI ET AL.: "FcR gamma chain deletion results in pleiotrophic effector cell defects", CELL, vol. 76, 11 February 1994 (1994-02-11), pages 519 - 529, XP002955801
See also references of EP 1449431A4
See also references of EP 1449431A4
Attorney, Agent or Firm:
Shimizu, Hatsushi (1-1-1 Oroshi-mach, Tsuchiura-shi Ibaraki, JP)
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