Title:
SHEEP-DERIVED LOW MOLECULAR WEIGHT HEPARIN, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/032502
Kind Code:
A1
Abstract:
A sheep-derived low molecular weight heparin, comprising sheep dalteparin sodium, sheep nadroparin calcium, sheep tinzaparin sodium, sheep parnaparin sodium, and sheep bemiparin sodium. The sheep-derived low molecular weight heparin has a common provenance characteristic, and in chemical structure, the content of the main disaccharide ΔUA2S-GlcNS6S(ΔIS) thereof is 66%-74%. The sheep-derived low molecular weight heparin has physical and chemical properties and biological activity similar to those of a pig-derived low molecular weight heparin, so that the source of low molecular weight heparin drugs is expanded. The method for preparing a sheep-derived low molecular weight heparin is simple and easy to implement, and the process is stable. The obtained product is refined and can meet the requirements of pharmacopoeias on the current low molecular weight heparin. The sheep-derived low molecular weight heparin also has the halal property that the pig-derived low molecular weight heparin lacks, has a huge market among Muslim groups, countries and regions, and can be applied in anticoagulant, antithrombotic, antiinflammatory, anticancer and halal drugs.
Inventors:
JIN YONGSHENG (CN)
JIN CAIJUAN (CN)
YAO YIMING (CN)
JIN CAIJUAN (CN)
YAO YIMING (CN)
Application Number:
PCT/CN2016/096030
Publication Date:
February 22, 2018
Filing Date:
August 19, 2016
Export Citation:
Assignee:
SUZHOU RONNSI PHARMA CO LTD (CN)
International Classes:
C08B37/10; A61K31/727
Foreign References:
| CN105294885A | 2016-02-03 | |||
| CN105131153A | 2015-12-09 | |||
| CN105343890A | 2016-02-24 | |||
| EP0293539B1 | 1994-06-08 | |||
| CN1283636A | 2001-02-14 | |||
| CN101831009A | 2010-09-15 |
Other References:
CHAPMAN, T. M. ET AL.: "Bemiparin A Review of its Use in the Prevention of Venous Thromboembolism and Treatment of Deep Vein Thrombosis", DRUGS, vol. 63, no. 21, 31 December 2003 (2003-12-31), pages 2357 - 2377
"Relationship of Bioengineered Heparin and Low Molecular Weight Heparin", CHINA DOCTORAL DISSERTATIONS FULL-TEXT DATABASE (ENGINEERING SCIENCE & TECHNOLOGY I.
"Relationship of Bioengineered Heparin and Low Molecular Weight Heparin", CHINA DOCTORAL DISSERTATIONS FULL-TEXT DATABASE (ENGINEERING SCIENCE & TECHNOLOGY I.
Attorney, Agent or Firm:
NANJING JINGWEI PATENT & TRADEMARK AGENCY CO., LTD (CN)
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