Title:
SHIP INHIBITORS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/127465
Kind Code:
A3
Abstract:
The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating graft versus host disease in a subject; (ii) a method of inhibiting a SHIP1 protein in a cell; (iii) a method of selectively inhibiting a SHIP1 protein in a cell; (iv) a method for treating or preventing graft-versus-host disease (GVHD) in a recipient of an organ or tissue transplant; (v) a method of modulating SHIP activity in a cell expressing SHIP1 or SHIP2; (vi) a method of ex vivo or in vitro treatment of transplants; (vii) a method of inhibiting tumor growth and metastasis in a subject; (viii) a method of treating a hematologic malignancy in a subject; (ix) a method of inducing apoptosis of multiple myeloma cells; (x) a method of treating multiple myeloma in a subject; (xi) a method of inhibiting the proliferation of a human breast cancer cell; and (xii) a method of treating breast cancer in a subject.
Inventors:
KERR WILLIAM G (US)
CHISHOLM JOHN D (US)
CHISHOLM JOHN D (US)
Application Number:
PCT/US2011/031930
Publication Date:
March 15, 2012
Filing Date:
April 11, 2011
Export Citation:
Assignee:
UNIV NEW YORK STATE RES FOUND (US)
SYRACUSE UNIVERSITY TECHNOLOGY TRANSFER AND IND DEV OFFICE (US)
KERR WILLIAM G (US)
CHISHOLM JOHN D (US)
SYRACUSE UNIVERSITY TECHNOLOGY TRANSFER AND IND DEV OFFICE (US)
KERR WILLIAM G (US)
CHISHOLM JOHN D (US)
International Classes:
C07C401/00; A61K31/56; A61K31/565; A61K31/575; A61P35/00
Domestic Patent References:
| WO2010045199A2 | 2010-04-22 | |||
| WO2008068037A1 | 2008-06-12 |
Foreign References:
| GB900572A | 1962-07-11 | |||
| BE702699A | 1968-01-15 |
Other References:
NIKOLAROPOULOS, SOTIRIOS ET AL.: "Formation of Acetamido-Aza-Steroids", J. HETEROCYCLIC CHEM., vol. 27, 1990, pages 1997 - 1999, XP055093508
PHILLIPPS, G. H. ET AL.: "A New Series of Steroidal Antidysrhythmic Agents", J. STEROID BIOCHEM., vol. 19, no. 1, 1983, pages 759 - 765, XP023413589
SYHORA, K. ET AL.: "Olefin-forming Elimination of the Amino Group", TETRAHEDRON LETT., vol. 28, 1965, pages 2369 - 2376, XP055093548
PHILLIPPS, G. H. ET AL.: "A New Series of Steroidal Antidysrhythmic Agents", J. STEROID BIOCHEM., vol. 19, no. 1, 1983, pages 759 - 765, XP023413589
SYHORA, K. ET AL.: "Olefin-forming Elimination of the Amino Group", TETRAHEDRON LETT., vol. 28, 1965, pages 2369 - 2376, XP055093548
Attorney, Agent or Firm:
GONSALVES, Andrew K. (5 Columbia CircleAlbany, New York, US)
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