Title:
SHORT BIOACTIVE PEPTIDES BLOCKING ACTIVITY OF ADVANCED GLYCATION END PRODUCTS, COMPOSITIONS, AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2018/085565
Kind Code:
A3
Abstract:
Advanced glycation end products (AGEs) represent a non-enzymatic post-translational protein modification. AGEs are very stable and the accumulation over time can be used as markers of carbonyl stress which are responsible for the malfunction of bioactive macromolecules in the body. Disclosed herein are a series of short peptides for blocking activity of advanced glycation end products (AGEs), the peptide being derived from a V-region of an sRAGE protein, wherein the V-region is given by SEQ ID NO:61. These peptides effectively inhibit the progress of a Maillard reaction, blocking the AGEs and inhibiting dicarbonyl induced cell apoptosis and death. The peptides can be used as, for example, an anti-glycation agent, a skin anti-aging agent, or an anti-diabetic complication agent.
Inventors:
ZHANG LIJUAN (US)
CARMICHAEL ROBIN (US)
CARMICHAEL ROBIN (US)
Application Number:
PCT/US2017/059756
Publication Date:
August 23, 2018
Filing Date:
November 02, 2017
Export Citation:
Assignee:
HELIX BIOMEDIX INC (US)
International Classes:
A61K38/00; A61K38/04; A61K38/06
Foreign References:
| US20100254983A1 | 2010-10-07 | |||
| US20080207499A1 | 2008-08-28 | |||
| US8088734B2 | 2012-01-03 | |||
| US20100249383A1 | 2010-09-30 | |||
| US20100040623A1 | 2010-02-18 | |||
| US20030216290A1 | 2003-11-20 | |||
| US20100028359A1 | 2010-02-04 |
Other References:
IWAMURA ET AL.: "Epidermal expression of receptor for advanced glycation end produc ts (RAGE) is related to inflammation and apoptosis in human skin", EXP DERMATOL, vol. 25, no. 3, 2016, pages 235 - 7, XP055535197
HORI ET AL.: "Experimental Models for Advanced Glycation End Product Formation Using Albumin, Collagen, Elastin, Keratin and Proteoglycan", ANTI-AGING MED., vol. 9, no. 5, 2012, pages 125 - 134, XP055535201
ZHANG ET AL.: "Receptor for Advanced Glycation End Products Is Subjected to Protein Ectodomain Shedding by Metalloproteinases", J BIOL CHEM., vol. 283, no. 51, 2008, pages 35507 - 16, XP055535232
HORI ET AL.: "Experimental Models for Advanced Glycation End Product Formation Using Albumin, Collagen, Elastin, Keratin and Proteoglycan", ANTI-AGING MED., vol. 9, no. 5, 2012, pages 125 - 134, XP055535201
ZHANG ET AL.: "Receptor for Advanced Glycation End Products Is Subjected to Protein Ectodomain Shedding by Metalloproteinases", J BIOL CHEM., vol. 283, no. 51, 2008, pages 35507 - 16, XP055535232
Attorney, Agent or Firm:
O'BRIEN, Daniel et al. (US)
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