Title:
SHORT PEPTIDE HAVING DENGUE VIRUS REPLICATION INHIBITION FUNCTION AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/137247
Kind Code:
A1
Abstract:
The present invention relates to the field of virology, and specifically discloses a short peptide having a dengue virus replication inhibition function and an application thereof. The amino acid sequence of the short peptide provided in the present invention is KHGHHRH, i.e. Lys-His-Gly-His-His-Arg-His. The short peptide has a high specificity affinity with NS5 and has the function of efficiently inhibiting dengue virus replication, the anti-viral effect thereof not been limited to DENV-2, but also having a significant inhibitory effect on the replication of type 1, type 3, and type 4 dengue virus. One cysteine is added to the two ends of the short peptide sequence, the short peptide being cyclised by means of the cysteines at the two ends to form a cyclic peptide. The obtained cyclic peptide strengthens the dengue virus replication inhibition function, and can be used for specific treatment of dengue virus infection.
Inventors:
WANG MINGLIAN (CN)
ZHANG TING (CN)
LI JINSONG (CN)
WANG QUN (CN)
YANG YISHU (CN)
LI JINTAO (CN)
LIU WEI (CN)
XIAO XIANGQIAN (CN)
SU XIAOJIN (CN)
ZHANG TING (CN)
LI JINSONG (CN)
WANG QUN (CN)
YANG YISHU (CN)
LI JINTAO (CN)
LIU WEI (CN)
XIAO XIANGQIAN (CN)
SU XIAOJIN (CN)
Application Number:
PCT/CN2018/124985
Publication Date:
July 18, 2019
Filing Date:
December 28, 2018
Export Citation:
Assignee:
UNIV BEIJING TECHNOLOGY (CN)
International Classes:
C07K7/06; A61K38/08; A61P31/14; C07K5/09; C07K5/11
Domestic Patent References:
| WO1994022488A1 | 1994-10-13 |
Foreign References:
| CN108395470A | 2018-08-14 |
Other References:
MATERA-WITKIEWICZ, A. ET AL.: "Short-chain Oligopeptides with Copper(II) Binding Properties: The Impact of Specific Structural Modifications on the Copper(II) Coordination Abilities", JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 103, no. 5, 9 January 2009 (2009-01-09), pages 678 - 688, XP026052690, ISSN: 0162-0134, DOI: 10.1016/j.jinorgbio.2009.01.001
MATERA-WITKIEWICZ, A. ET AL.: "Interactions between Ni2+ions and Tetrapeptides Containing (Asp/Lys)HisGly(IJD)His Sequence", POLYHEDRON, vol. 29, no. 16, 18 August 2010 (2010-08-18)
MENDOLA, D.L. ET AL.: "Copper(II) Interaction with Peptide Fragments of Histidine-proline- rich Glycoprotein: Speciation, Stability and Binding Details", JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 111, 6 March 2012 (2012-03-06), pages 59 - 69, XP028519352, ISSN: 0162-0134, DOI: 10.1016/j.jinorgbio.2012.02.027
IDRUS, S. ET AL.: "Designing Cyclopentapeptide Inhibitor as Potential Antiviral Drug for Dengue Virus ns5 Methyltransferase", BIOINFORMATION, vol. 8, no. 8, 30 April 2012 (2012-04-30), pages 348 - 352, XP055625118
MATERA-WITKIEWICZ, A. ET AL.: "Interactions between Ni2+ions and Tetrapeptides Containing (Asp/Lys)HisGly(IJD)His Sequence", POLYHEDRON, vol. 29, no. 16, 18 August 2010 (2010-08-18)
MENDOLA, D.L. ET AL.: "Copper(II) Interaction with Peptide Fragments of Histidine-proline- rich Glycoprotein: Speciation, Stability and Binding Details", JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 111, 6 March 2012 (2012-03-06), pages 59 - 69, XP028519352, ISSN: 0162-0134, DOI: 10.1016/j.jinorgbio.2012.02.027
IDRUS, S. ET AL.: "Designing Cyclopentapeptide Inhibitor as Potential Antiviral Drug for Dengue Virus ns5 Methyltransferase", BIOINFORMATION, vol. 8, no. 8, 30 April 2012 (2012-04-30), pages 348 - 352, XP055625118
Attorney, Agent or Firm:
CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED (CN)
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