Title:
SHP2 INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/061263
Kind Code:
A1
Abstract:
Provided is the following compound or a pharmaceutically acceptable salt, ester, optical isomer, stereoisomer, polymorphic substance, solvate, N-oxide, isotope-labeled compound, metabolite, chelate, coordination complex, inclusion compound or prodrug thereof, and a pharmaceutical composition comprising the compound. Also provided is an application of the compound in preparing a drug for a disease associated with SHP2 phosphatase. Also provided is a method for treating a disease associated with SHP2 phosphatase.
Inventors:
LI WENMING (CN)
LI XIAOBO (CN)
LU PENG (CN)
PIAO MINGNAN (CN)
WANG NING (CN)
YU GUOKUN (CN)
LIU JUNRONG (CN)
ZHANG YU (CN)
YU TIANTIAN (CN)
LI XIAOBO (CN)
LU PENG (CN)
PIAO MINGNAN (CN)
WANG NING (CN)
YU GUOKUN (CN)
LIU JUNRONG (CN)
ZHANG YU (CN)
YU TIANTIAN (CN)
Application Number:
PCT/CN2022/123863
Publication Date:
April 20, 2023
Filing Date:
October 08, 2022
Export Citation:
Assignee:
BEIJING TIDE PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D311/04; A61K31/352; A61K31/403; A61P35/00; C07D209/02; C07D405/14
Domestic Patent References:
| WO2020063760A1 | 2020-04-02 | |||
| WO2020201991A1 | 2020-10-08 |
Foreign References:
| CN112166110A | 2021-01-01 |
Other References:
VEMULAPALLI VIDYASIRI, DONOVAN KATHERINE A., SEEGAR TOM C. M., ROGERS JULIA M., BAE MUNHYUNG, LUMPKIN RYAN J., CAO RUILI, HENKE MA: "Targeted Degradation of the Oncogenic Phosphatase SHP2", BIOCHEMISTRY, vol. 60, no. 34, 31 August 2021 (2021-08-31), pages 2593 - 2609, XP093056072, ISSN: 0006-2960, DOI: 10.1021/acs.biochem.1c00377
ZHENG, MENGZHU ET AL.: "Novel PROTACs for degradation of SHP2 protein.", BIOORGANIC CHEMISTRY, vol. 110, 1 March 2021 (2021-03-01), XP086552081, DOI: 10.1016/j.bioorg.2021.104788
YANG, X. ET AL.: "Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders.", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 218, 11 March 2021 (2021-03-11), XP086560058, DOI: 10.1016/j.ejmech.2021.113341
LIU MENG, GAO SHAN, ELHASSAN REHAM M., HOU XUBEN, FANG HAO: "Strategies to overcome drug resistance using SHP2 inhibitors", ACTA PHARMACEUTICA SINICA B, vol. 11, no. 12, 1 December 2021 (2021-12-01), pages 3908 - 3924, XP093056075, ISSN: 2211-3835, DOI: 10.1016/j.apsb.2021.03.037
K. S. GROSSMAN ET AL., ADV. CANCER RES., vol. 106, 2010, pages 53 - 89
G. W. H. CHEESEMANE. S. G. WERSTIUK: "PrO—drugs as Novel Delivery Systems", vol. 14, 1985, ACS SYMPOSIUM SERIES, pages: 390 - 392
T. W. GREENEP. G. M. WUTS: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY & SONS
ZHENG, MENGZHU ET AL.: "Novel PROTACs for degradation of SHP2 protein.", BIOORGANIC CHEMISTRY, vol. 110, 1 March 2021 (2021-03-01), XP086552081, DOI: 10.1016/j.bioorg.2021.104788
YANG, X. ET AL.: "Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders.", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 218, 11 March 2021 (2021-03-11), XP086560058, DOI: 10.1016/j.ejmech.2021.113341
LIU MENG, GAO SHAN, ELHASSAN REHAM M., HOU XUBEN, FANG HAO: "Strategies to overcome drug resistance using SHP2 inhibitors", ACTA PHARMACEUTICA SINICA B, vol. 11, no. 12, 1 December 2021 (2021-12-01), pages 3908 - 3924, XP093056075, ISSN: 2211-3835, DOI: 10.1016/j.apsb.2021.03.037
K. S. GROSSMAN ET AL., ADV. CANCER RES., vol. 106, 2010, pages 53 - 89
G. W. H. CHEESEMANE. S. G. WERSTIUK: "PrO—drugs as Novel Delivery Systems", vol. 14, 1985, ACS SYMPOSIUM SERIES, pages: 390 - 392
T. W. GREENEP. G. M. WUTS: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY & SONS
Attorney, Agent or Firm:
FIWIS INTELLECTUAL PROPERTY LAW FIRM (CN)
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