Title:
SIALIC ACID (α-(2→6))-D-AMINOPYRAN GALACTOSE DERIVATIVE OR SALT THEREOF, GLYCOCONJUGATE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2024/078578
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of oligosaccharides and glycoconjugates thereof, and specifically relates to a sialic acid (α-(2→6))-D-aminopyran galactose derivative or a salt thereof, a glycoconjugate and a preparation method therefor. Provided are a nitrogen-linked sialic acid (α-(2→6))-D-aminopyran galactose derivative or a salt thereof, which has a structure as shown in formula 1. Experiments in mice show that the nitrogen-linked sialic acid (α-(2→6))-D-aminopyran galactose derivative or a salt thereof can be coupled with a carrier protein or a polypeptide via different linkers to obtain a glycoprotein (glycopeptide) conjugate, which generates a more effective immune response, and can specifically recognize tumor cells expressing STn, thereby achieving an anti-tumor effect. The present invention provides a new skeleton structure for the research on and development of anti-tumor carbohydrate vaccines, and is expected to promote the development of anti-tumor carbohydrate vaccines.
Inventors:
YE XINSHAN (CN)
HUO CHANGXIN (CN)
ZHENG XIUJING (CN)
XU CHENGHAO (CN)
HUO CHANGXIN (CN)
ZHENG XIUJING (CN)
XU CHENGHAO (CN)
Application Number:
PCT/CN2023/124243
Publication Date:
April 18, 2024
Filing Date:
October 12, 2023
Export Citation:
Assignee:
UNIV BEIJING (CN)
International Classes:
C07K14/795; A61K31/7028; A61K39/00; A61K39/385; A61P35/00; C07H15/10; C07K1/107; C07K14/34; C07K14/765
Attorney, Agent or Firm:
BEIJING GAOWO LAW FIRM (CN)
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