Title:
SIGMA RECEPTOR LIGANDS FOR MODULATING CELLULAR PROTEIN HOMEOSTASIS
Document Type and Number:
WIPO Patent Application WO/2014/015157
Kind Code:
A3
Abstract:
The present invention includes compounds useful in preventing, treating or ameliorating Sigma-related disorders or diseases. The compounds of the invention may modulate cellular protein homeostasis, which includes: translation initiation, folding, processing, transport, and degradation (including ubiquitin selective autophagy) of proteins. The present invention also includes methods of preventing, treating or ameliorating a Sigma-related disorder or disease in a subject in need thereof, the method comprising administering to the subject an effective amount of a Sigma-modulating compound. The present invention also includes methods of preventing, treating or ameliorating a Sigma-related disorder or disease in a subject in need thereof, the method comprising administering to the subject an effective amount of a Sigma-modulating compound, further comprising administering an effective amount of a compound that inhibits the ubiquitin proteasome system (UPS) and/or autophagic survival pathways.
Inventors:
KIM FELIX J (US)
SALVINO JOSEPH M (US)
SALVINO JOSEPH M (US)
Application Number:
PCT/US2013/051110
Publication Date:
April 24, 2014
Filing Date:
July 18, 2013
Export Citation:
Assignee:
PHILADELPHIA HEALTH & EDUCATIO (US)
International Classes:
C07C277/00
Foreign References:
| US20050192314A1 | 2005-09-01 | |||
| US5385946A | 1995-01-31 |
Other References:
DING, WX ET AL.: "Linking of Autophagy to Ubiquitin-Proteasome System is Important for the Regulation of Endoplasmic Reticulum Stress and Cell Viability", AMERICAN JOUMAL OF PATHOLOGY, vol. 171, no. 2, August 2007 (2007-08-01), pages 513 - 524, XP009126303
Attorney, Agent or Firm:
ORBIN, Alia M. et al. (LLP300 Four Falls Corporate Center, Suite 710,300 Conshohocken State Roa, West Conshohocken PA, US)
Download PDF:
Previous Patent: ELONGATE MEDICAL DEVICE WITH ARTICULATING PORTION
Next Patent: SLIDING JOINT FOR USE WITH A DOWNHOLE TOOL
Next Patent: SLIDING JOINT FOR USE WITH A DOWNHOLE TOOL