Title:
A SIMULTANEOUSLY ANTIMICROBIAL AND PROTEIN-REPELLENT POLYZWITTERION
Document Type and Number:
WIPO Patent Application WO/2018/091467
Kind Code:
A3
Abstract:
The present invention concerns a simultaneously antimicrobial and antifouling and protein repellent polyzwitterion (monolayers, polymer networks and surface-attached polymer networks formed thereby), and substrates coated with the inventive simultaneously antimicrobial and antifouling and protein repellent polyzwitterion. The invention also concerns uses of the inventive polymers and substrates for preventing and combating microbial growth.
Inventors:
LIENKAMP KAREN (DE)
KUROWSKA MONIKA (DE)
GUEVARA-SOLARTE DIANA (DE)
HETTLER ALICE (DE)
AL-AHMAD ALI (DE)
RIGA ESTHER (DE)
KUROWSKA MONIKA (DE)
GUEVARA-SOLARTE DIANA (DE)
HETTLER ALICE (DE)
AL-AHMAD ALI (DE)
RIGA ESTHER (DE)
Application Number:
PCT/EP2017/079205
Publication Date:
July 12, 2018
Filing Date:
November 14, 2017
Export Citation:
Assignee:
UNIV FREIBURG ALBERT LUDWIGS (DE)
International Classes:
C09D5/14; A01N25/10; A01N43/08; A01N47/44; A61L29/08; C08G61/08; C09D5/16
Domestic Patent References:
| WO2007136738A2 | 2007-11-29 | |||
| WO2007045634A2 | 2007-04-26 |
Foreign References:
| EP2471827A1 | 2012-07-04 | |||
| EP2636693A1 | 2013-09-11 | |||
| US20100317870A1 | 2010-12-16 | |||
| US20100210803A1 | 2010-08-19 |
Other References:
SEMRA COLAK ET AL: "Dual-Functional ROMP-Based Betaines: Effect of Hydrophilicity and Backbone Structure on Nonfouling Properties", LANGMUIR, vol. 28, no. 1, 10 January 2012 (2012-01-10), pages 666 - 675, XP055036254, ISSN: 0743-7463, DOI: 10.1021/la203683u
PENG ZOU ET AL: "Antimicrobial and cell-compatible surface-attached polymer networks - how the correlation of chemical structure to physical and biological data leads to a modified mechanism of action", JOURNAL OF MATERIALS CHEMISTRY B, vol. 3, no. 30, 1 January 2015 (2015-01-01), GB, pages 6224 - 6238, XP055444944, ISSN: 2050-750X, DOI: 10.1039/C5TB00906E
PENG ZOU ET AL: "It takes walls and knights to defend a castle - synthesis of surface coatings from antimicrobial and antibiofouling polymers", JOURNAL OF MATERIALS CHEMISTRY, vol. 22, no. 37, 1 January 2012 (2012-01-01), GB, pages 19579, XP055444961, ISSN: 0959-9428, DOI: 10.1039/c2jm31695a
WIBKE HARTLEB ET AL: "Just Antimicrobial is not Enough: Toward Bifunctional Polymer Surfaces with Dual Antimicrobial and Protein-Repellent Functionality", MACROMOLECULAR CHEMISTRY AND PHYSICS., vol. 217, no. 2, 1 January 2016 (2016-01-01), DE, pages 225 - 231, XP055444974, ISSN: 1022-1352, DOI: 10.1002/macp.201500266
ILKER M F ET AL: "Modular Nobornene Derivatives for the Preparation of Well-Defined Amphiphilic Polymers: Study of the Lipid Membrane Disruption Activities", MACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 37, no. 3, 16 January 2004 (2004-01-16), pages 694 - 700, XP002364604, ISSN: 0024-9297, DOI: 10.1021/MA035407D
CANSU ERGENE ET AL: "Biomimetic antimicrobial polymers: recent advances in molecular design", POLYMER CHEMISTRY, vol. 9, no. 18, 1 January 2018 (2018-01-01), GB, pages 2407 - 2427, XP055478499, ISSN: 1759-9954, DOI: 10.1039/C8PY00012C
JOEL M. SARAPAS ET AL: "ROMP- and RAFT-Based Guanidinium-Containing Polymers as Scaffolds for Protein Mimic Synthesis", CHEMISTRY - A EUROPEAN JOURNAL, vol. 23, no. 28, 17 May 2017 (2017-05-17), DE, pages 6858 - 6863, XP055478508, ISSN: 0947-6539, DOI: 10.1002/chem.201700423
PENG ZOU ET AL: "Antimicrobial and cell-compatible surface-attached polymer networks - how the correlation of chemical structure to physical and biological data leads to a modified mechanism of action", JOURNAL OF MATERIALS CHEMISTRY B, vol. 3, no. 30, 1 January 2015 (2015-01-01), GB, pages 6224 - 6238, XP055444944, ISSN: 2050-750X, DOI: 10.1039/C5TB00906E
PENG ZOU ET AL: "It takes walls and knights to defend a castle - synthesis of surface coatings from antimicrobial and antibiofouling polymers", JOURNAL OF MATERIALS CHEMISTRY, vol. 22, no. 37, 1 January 2012 (2012-01-01), GB, pages 19579, XP055444961, ISSN: 0959-9428, DOI: 10.1039/c2jm31695a
WIBKE HARTLEB ET AL: "Just Antimicrobial is not Enough: Toward Bifunctional Polymer Surfaces with Dual Antimicrobial and Protein-Repellent Functionality", MACROMOLECULAR CHEMISTRY AND PHYSICS., vol. 217, no. 2, 1 January 2016 (2016-01-01), DE, pages 225 - 231, XP055444974, ISSN: 1022-1352, DOI: 10.1002/macp.201500266
ILKER M F ET AL: "Modular Nobornene Derivatives for the Preparation of Well-Defined Amphiphilic Polymers: Study of the Lipid Membrane Disruption Activities", MACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 37, no. 3, 16 January 2004 (2004-01-16), pages 694 - 700, XP002364604, ISSN: 0024-9297, DOI: 10.1021/MA035407D
CANSU ERGENE ET AL: "Biomimetic antimicrobial polymers: recent advances in molecular design", POLYMER CHEMISTRY, vol. 9, no. 18, 1 January 2018 (2018-01-01), GB, pages 2407 - 2427, XP055478499, ISSN: 1759-9954, DOI: 10.1039/C8PY00012C
JOEL M. SARAPAS ET AL: "ROMP- and RAFT-Based Guanidinium-Containing Polymers as Scaffolds for Protein Mimic Synthesis", CHEMISTRY - A EUROPEAN JOURNAL, vol. 23, no. 28, 17 May 2017 (2017-05-17), DE, pages 6858 - 6863, XP055478508, ISSN: 0947-6539, DOI: 10.1002/chem.201700423
Attorney, Agent or Firm:
GRINDL, Wolfgang (DE)
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