SINGLE-CHAIN IL-2/ANTIBODY FUSIONS THAT SELECTIVELY ACTIVATE REGULATORY T CELLS

Title:

SINGLE-CHAIN IL-2/ANTIBODY FUSIONS THAT SELECTIVELY ACTIVATE REGULATORY T CELLS

Document Type and Number:

WIPO Patent Application WO/2019/168791

Kind Code:

A3

Abstract:

Antibody-IL-2 single-chain fusions (immunocytokines) with selective activity in expansion of T cell subsets are provided herein. Methods of use include administering an agent of the invention to expand particular immune cell subpopulations as a research tool or to treat disease or disease models through induction of selective IL-2 activity.

Inventors:

GARCIA KENAN CHRISTOPHER (US)
SPANGLER JAMIE (US)
BLUESTONE JEFFREY A (US)
TROTTA ELEANORA (US)

Application Number:

PCT/US2019/019421

Publication Date:

November 21, 2019

Filing Date:

February 25, 2019

Export Citation:

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Assignee:

UNIV LELAND STANFORD JUNIOR (US)
UNIV CALIFORNIA (US)

International Classes:

A61K38/20; C07K16/24

Domestic Patent References:

WO2017122130A1

2017-07-20

Foreign References:

US20090098609A1	2009-04-16
US20020106369A1	2002-08-08
US20110059097A1	2011-03-10

Attorney, Agent or Firm:

SHERWOOD, Pamela J. (US)

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