SINGLE-DOMAIN ANTIBODIES AND VARIANTS THEREOF AGAINST CTLA-4

Title:

SINGLE-DOMAIN ANTIBODIES AND VARIANTS THEREOF AGAINST CTLA-4

Document Type and Number:

WIPO Patent Application WO/2018/068695

Kind Code:

A1

Abstract:

The present application provides constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes CTLA-4. Also provided are methods of making and using these constructs.

Inventors:

ZHANG YAFENG (CN)
WU SHU (CN)
YANG SHUAI (CN)
CHOU CHUAN-CHU (US)

Application Number:

PCT/CN2017/105506

Publication Date:

April 19, 2018

Filing Date:

October 10, 2017

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Assignee:

NANJING LEGEND BIOTECH CO LTD (CN)

International Classes:

C07K16/28; A61K39/395; A61P35/00; C07K16/46; C12N15/13

Foreign References:

EP1792991A1

2007-06-06

Other References:

JIN, H.: "Construction and Characterization of a CTLA-4-Targeted scFv-Melittin Fusion Protein as a Potential Immunosuppressive Agent for Organ Transplant", CELL BIOCHEMISTRY AND BIOPHYSICS, vol. 67, no. 3, 31 December 2013 (2013-12-31), pages 1067 - 1074, XP055475820
See also references of EP 3526258A4

Attorney, Agent or Firm:

CHENG & PENG INTELLECTUAL PROPERTY LAW OFFICE (CN)

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