Title:
SINGLE DOMAIN ANTIBODY AGAINST SARS-COV-2, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/103245
Kind Code:
A1
Abstract:
The present invention relates to a single domain antibody against SARS-CoV-2, and the use thereof. Particularly, a single domain antibody, specifically binding to the receptor-binding domain (RBD) of a SARS-CoV-2 spike glycoprotein, has been produced and confirmed to have excellent affinity to the RBD and excellent in vitro and in vivo neutralization capacity against SARS-CoV-2. Therefore, an antibody comprising the single domain antibody of the present invention or an antigen-binding fragment thereof can be utilized as an active ingredient of a pharmaceutical composition for preventing or treating COVID-19. Further, the antibody comprising the single domain antibody or the antigen-binding fragment thereof can be utilized for COVID-19 diagnosis.
Inventors:
SEONG SEUNG YONG (KR)
KIM JEONG HWAN (KR)
LEE SANG BEUM (KR)
JEONG HYOUNG HWA (KR)
YANG HYE YOUNG (KR)
KIM BUM JOON (KR)
KIM SEONG EUN (KR)
KIM JEONG HWAN (KR)
LEE SANG BEUM (KR)
JEONG HYOUNG HWA (KR)
YANG HYE YOUNG (KR)
KIM BUM JOON (KR)
KIM SEONG EUN (KR)
Application Number:
PCT/KR2021/095101
Publication Date:
May 19, 2022
Filing Date:
November 10, 2021
Export Citation:
Assignee:
SHAPERON INC (KR)
HUVETBIO INC (KR)
SEOUL NAT UNIV R&DB FOUNDATION (KR)
HUVETBIO INC (KR)
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
C07K16/10; A61K39/00; A61P31/14; G01N33/569; G01N33/68
Foreign References:
| CN111825762A | 2020-10-27 |
Other References:
DATABASE PROTEIN 20 September 2020 (2020-09-20), ANONYMOUS : "anti-SARS-CoV-2 immunoglobulin heavy chain variable region, partial [Lama glama] ", XP055930070, retrieved from NCBI Database accession no. QNS17504
CHI XIAOJING, LIU XIUYING, WANG CONGHUI, ZHANG XINHUI, LI XIANG, HOU JIANHUA, REN LILI, JIN QI, WANG JIANWEI, YANG WEI: "Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain", NATURE COMMUNICATIONS, vol. 11, no. 1, 1 December 2020 (2020-12-01), XP055788434, DOI: 10.1038/s41467-020-18387-8
WU YANLING; LI CHENG; XIA SHUAI; TIAN XIAOLONG; KONG YU; WANG ZHI; GU CHENJIAN; ZHANG RONG; TU CHAO; XIE YOUHUA; YANG ZHENLIN; LU : "Identification of Human Single-Domain Antibodies against SARS-CoV-2", CELL HOST & MICROBE, ELSEVIER, NL, vol. 27, no. 6, 14 May 2020 (2020-05-14), NL , pages 891, XP086178478, ISSN: 1931-3128, DOI: 10.1016/j.chom.2020.04.023
DANIEL WRAPP, DE VLIEGER DORIEN, CORBETT KIZZMEKIA S., TORRES GRETEL M., WANG NIANSHUANG, VAN BREEDAM WANDER, ROOSE KENNY, VAN SCH: "Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies", CELL, ELSEVIER, AMSTERDAM NL, vol. 181, no. 5, 28 May 2020 (2020-05-28), Amsterdam NL , pages 1004 - 1015.e15, XP055764639, ISSN: 0092-8674, DOI: 10.1016/j.cell.2020.04.031
CHI XIAOJING, LIU XIUYING, WANG CONGHUI, ZHANG XINHUI, LI XIANG, HOU JIANHUA, REN LILI, JIN QI, WANG JIANWEI, YANG WEI: "Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain", NATURE COMMUNICATIONS, vol. 11, no. 1, 1 December 2020 (2020-12-01), XP055788434, DOI: 10.1038/s41467-020-18387-8
WU YANLING; LI CHENG; XIA SHUAI; TIAN XIAOLONG; KONG YU; WANG ZHI; GU CHENJIAN; ZHANG RONG; TU CHAO; XIE YOUHUA; YANG ZHENLIN; LU : "Identification of Human Single-Domain Antibodies against SARS-CoV-2", CELL HOST & MICROBE, ELSEVIER, NL, vol. 27, no. 6, 14 May 2020 (2020-05-14), NL , pages 891, XP086178478, ISSN: 1931-3128, DOI: 10.1016/j.chom.2020.04.023
DANIEL WRAPP, DE VLIEGER DORIEN, CORBETT KIZZMEKIA S., TORRES GRETEL M., WANG NIANSHUANG, VAN BREEDAM WANDER, ROOSE KENNY, VAN SCH: "Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies", CELL, ELSEVIER, AMSTERDAM NL, vol. 181, no. 5, 28 May 2020 (2020-05-28), Amsterdam NL , pages 1004 - 1015.e15, XP055764639, ISSN: 0092-8674, DOI: 10.1016/j.cell.2020.04.031
Attorney, Agent or Firm:
KIM, Bo Jung (KR)
Download PDF:
Previous Patent: POLYIMIDE FILM FOR GRAPHITE SHEET, AND GRAPHITE SHEET MANUFACTURED THEREFROM
Next Patent: LASER CUTTING SYSTEM
Next Patent: LASER CUTTING SYSTEM