Title:
SINGLE-DOMAIN ANTIBODY CAPABLE OF RECOGNIZING HUMAN SERUM ALBUMIN
Document Type and Number:
WIPO Patent Application WO/2018/121473
Kind Code:
A1
Abstract:
Provided is a single-domain antibody capable of recognizing human serum albumin (HSA). By adopting a phage display technology, multiple strains of antibodies capable of specifically recognizing HSA are obtained by screening in a human single-domain antibody library. The antibodies contain only one variable region of an antibody heavy chain and are the smallest fully functional antigen-binding fragments, and have a smaller molecular weight and weaker immunogenicity than a single-chain antibody or antibody Fab fragment, and can function to extend the half-life of biological drugs when specifically bound to HSA. Single-domain antibodies with a high affinity are obtained by screening, and the antibodies can recognize specific human serum albumin and extend the half-life of biological drugs, facilitating the treatment of tumors.
Inventors:
LV LIHUI (CN)
GAO BIN (CN)
GU MINGZHU (CN)
LIU YING (CN)
LIANG MENG (CN)
GAO BIN (CN)
GU MINGZHU (CN)
LIU YING (CN)
LIANG MENG (CN)
Application Number:
PCT/CN2017/118281
Publication Date:
July 05, 2018
Filing Date:
December 25, 2017
Export Citation:
Assignee:
TIMMUNE BIOTECH INC (CN)
International Classes:
C07K16/18; A61P35/00; C07K19/00; C12N1/21; C12N5/10; C12N15/62
Domestic Patent References:
| WO2004041865A2 | 2004-05-21 |
Foreign References:
| CN105315374A | 2016-02-10 | |||
| CN104974263A | 2015-10-14 | |||
| CN104740631A | 2015-07-01 | |||
| CN105646643A | 2016-06-08 | |||
| CN103547592A | 2014-01-29 |
Attorney, Agent or Firm:
JEEKAI & PARTNERS (CN)
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