Title:
SINGLE DOMAIN ANTIBODY TARGETING αVβ3 INTEGRIN
Document Type and Number:
WIPO Patent Application WO/2021/015336
Kind Code:
A1
Abstract:
The present invention relates to a single domain antibody targeting αvβ3 integrin and various applications thereof. The single domain antibody targeting αvβ3 integrin of the present invention exhibits high avidity for αvβ3 integrin associated with neovascularization, and excellent tissue penetrability and biostability, compared to conventional antibodies. In addition, the single domain antibody of the present invention can be simply measured in vitro, in vivo or ex vivo by binding to fluorescent particles, and is thereby effective in detecting angiogenesis and diagnosing related diseases, and thus can be advantageously used in related industries.
Inventors:
CHANG KI-YUK (KR)
HONG KWAN-SOO (KR)
PARK HYO-EUN (KR)
KIM EUN-MIN (KR)
PARK EUN-HYE (KR)
KIM CHAN-WOO (KR)
KANG KWON-YOON (KR)
LEE HYUN-SEUNG (KR)
KIM HYUN-MIN (KR)
HONG KWAN-SOO (KR)
PARK HYO-EUN (KR)
KIM EUN-MIN (KR)
PARK EUN-HYE (KR)
KIM CHAN-WOO (KR)
KANG KWON-YOON (KR)
LEE HYUN-SEUNG (KR)
KIM HYUN-MIN (KR)
Application Number:
PCT/KR2019/009144
Publication Date:
January 28, 2021
Filing Date:
July 24, 2019
Export Citation:
Assignee:
CATHOLIC UNIV KOREA IND ACADEMIC COOPERATION FOUNDATION (KR)
KOREA BASIC SCIENCE INST (KR)
KOREA BASIC SCIENCE INST (KR)
International Classes:
C07K16/28; A61K51/10; G01N33/574; G01N33/58; G01N33/68
Domestic Patent References:
| WO2018183894A1 | 2018-10-04 |
Foreign References:
| US20090053238A1 | 2009-02-26 | |||
| US6369204B1 | 2002-04-09 | |||
| US20080175840A1 | 2008-07-24 | |||
| US6171588B1 | 2001-01-09 | |||
| KR20190108308A | 2019-09-24 | |||
| US4554101A | 1985-11-19 |
Other References:
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CORTEZ-RETAMOZO, V ET AL., CANCER RES., vol. 64, 2004, pages 2853 - 2857
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DUMOULIN, M ET AL., PROTEIN SCIII, vol. 11, 2002, pages 500 - 515
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H. NEURATHR.L. HILL: "The Proteins", 1979, ACADEMIC PRESS
SAMBROOK ET AL.: "A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS, article "Molecular Cloning"
YANOFSKY, C, J. BACTERIOL., vol. 158, 1984, pages 1018 - 1024
HERSKOWITZ, IHAGEN, D, ANN. REV. GENET., vol. 14, 1980, pages 399 - 445
COHEN , SN ET AL., PROC. NATL. ACAC. SCI. USA, vol. 9, 1973, pages 2110 - 2114
HANAHAN, D, J. MOL. BIOL., vol. 166, 1983, pages 557 - 580
DOWER, W.J. ET AL., NUCLEIC. ACIDS RES., vol. 16, 1988, pages 6127 - 6145
HAMERS-CASTERMAN, C ET AL., NATURE, vol. 363, 1993, pages 446 - 448
CORTEZ-RETAMOZO, V ET AL., CANCER RES., vol. 64, 2004, pages 2853 - 2857
ARBABI-GHAHROUDII, M ET AL., FEBS LETT, vol. 414, pages 521 - 526
DUMOULIN, M ET AL., PROTEIN SCIII, vol. 11, 2002, pages 500 - 515
DUMOULIN, M ET AL., NATURE, vol. 424, 2003, pages 783 - 788
H. NEURATHR.L. HILL: "The Proteins", 1979, ACADEMIC PRESS
SAMBROOK ET AL.: "A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS, article "Molecular Cloning"
YANOFSKY, C, J. BACTERIOL., vol. 158, 1984, pages 1018 - 1024
HERSKOWITZ, IHAGEN, D, ANN. REV. GENET., vol. 14, 1980, pages 399 - 445
COHEN , SN ET AL., PROC. NATL. ACAC. SCI. USA, vol. 9, 1973, pages 2110 - 2114
HANAHAN, D, J. MOL. BIOL., vol. 166, 1983, pages 557 - 580
DOWER, W.J. ET AL., NUCLEIC. ACIDS RES., vol. 16, 1988, pages 6127 - 6145
Attorney, Agent or Firm:
WIE, Byoung-Gap (KR)
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