Title:
SINGLE NUCLEOTIDE POLYMORPHISM FOR DIAGNOSIS OF RECURRENCE OF HEPATOCELLULAR CARCINOMA
Document Type and Number:
WIPO Patent Application WO/2011/118968
Kind Code:
A2
Abstract:
The present invention relates to a single nucleotide polymorphism (SNP) for diagnosis of recurrence of hepatocellular carcinoma, wherein the SNP shows a significant correlation with the risk of recurrence after hepatocellular carcinoma surgery. Therefore, the SNP can be used in developing micro-arrays or diagnosis kits for diagnosis of recurrence of hepatocellular carcinoma, and in screening drugs for preventing recurrence of hepatocellular carcinoma to thereby prevent recurrence of hepatocellular carcinoma after surgery.
Inventors:
CHUNG YOUNG-HWA (KR)
YU EUN-SIL (KR)
LEE YOUNG-JOO (KR)
KIM JEONG-A (KR)
LEE JONG-EUN (KR)
YU EUN-SIL (KR)
LEE YOUNG-JOO (KR)
KIM JEONG-A (KR)
LEE JONG-EUN (KR)
Application Number:
PCT/KR2011/001965
Publication Date:
September 29, 2011
Filing Date:
March 22, 2011
Export Citation:
Assignee:
UNIV ULSAN FOUND FOR IND COOP (KR)
CHUNG YOUNG-HWA (KR)
YU EUN-SIL (KR)
LEE YOUNG-JOO (KR)
KIM JEONG-A (KR)
LEE JONG-EUN (KR)
CHUNG YOUNG-HWA (KR)
YU EUN-SIL (KR)
LEE YOUNG-JOO (KR)
KIM JEONG-A (KR)
LEE JONG-EUN (KR)
International Classes:
C12Q1/68; C12N15/11; G01N33/15
Other References:
DATABASE NCBI 16 July 2005 Database accession no. rs3741208
DATABASE NCBI 26 February 2008 Database accession no. rs2585
DATABASE NCBI 28 August 2007 Database accession no. rs2239681
DATABASE NCBI 17 October 2007 Database accession no. rs3802971
KIM, Y. J. ET AL.: 'IGF2 polymorphisms are associated with hepatitis B virus clearance and hepatocellular carcinoma' BIOCHEM. BIOPHYS. RES. COMMUN. vol. 346, no. 1, 21 July 2006, pages 38 - 44
TAKEDA, S.: 'Allelic-expression imbalance of the insulin-like growth factor 2 gene in hepatocellular carcinoma and underlying disease' ONCOGENE vol. 12, no. 7, 04 April 1996, pages 1589 - 1592
DATABASE NCBI 26 February 2008 Database accession no. rs2585
DATABASE NCBI 28 August 2007 Database accession no. rs2239681
DATABASE NCBI 17 October 2007 Database accession no. rs3802971
KIM, Y. J. ET AL.: 'IGF2 polymorphisms are associated with hepatitis B virus clearance and hepatocellular carcinoma' BIOCHEM. BIOPHYS. RES. COMMUN. vol. 346, no. 1, 21 July 2006, pages 38 - 44
TAKEDA, S.: 'Allelic-expression imbalance of the insulin-like growth factor 2 gene in hepatocellular carcinoma and underlying disease' ONCOGENE vol. 12, no. 7, 04 April 1996, pages 1589 - 1592
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
특허법인 태백 (KR)
특허법인 태백 (KR)
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Claims:
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