Title:
SINGLE NUCLEOTIDE POLYMORPHISM MARKER FOR PREDICTING RISK OF ALZHEIMER'S DISEASE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/114526
Kind Code:
A1
Abstract:
The present invention relates to: a method for providing information that enables early diagnosis and prediction of a risk group for Alzheimer's disease by providing an SNP marker that can predict high risk of Alzheimer's disease in Korean people; a composition for predicting the risk of Alzheimer's disease; and a microarray and a kit including the composition.
Inventors:
WON SUNG HO (KR)
PARK JUN YOUNG (KR)
LEE KUN HO (KR)
PARK JUN YOUNG (KR)
LEE KUN HO (KR)
Application Number:
PCT/KR2021/014469
Publication Date:
June 02, 2022
Filing Date:
October 18, 2021
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
UNIV CHOSUN IACF (KR)
NEUROZEN INC (KR)
UNIV CHOSUN IACF (KR)
NEUROZEN INC (KR)
International Classes:
C12Q1/6883
Foreign References:
| KR20180053432A | 2018-05-21 |
Other References:
LEE DONGSOO: "Genome-wide assessment of MRI traits implicates SHARPIN in Alzheimer pathogenesis", THESIS, DEPARTMENT OF PUBLIC HEALTH, THE GRADUATE SCHOOL OF PUBLIC HEALTH SEOUL NATIONAL UNIVERSITY, 1 February 2020 (2020-02-01), pages 1 - 49, XP055933554
ASANOMI YUYA, SHIGEMIZU DAICHI, MIYASHITA AKINORI, MITSUMORI RISA, MORI TAIKI, HARA NORIKAZU, ITO KAORU, NIIDA SHUMPEI, IKEUCHI TA: "A rare functional variant of SHARPIN attenuates the inflammatory response and associates with increased risk of late-onset Alzheimer’s disease", MOLECULAR MEDICINE, vol. 25, no. 20, 1 December 2019 (2019-12-01), Washington , DC , pages 1 - 9, XP055933559, ISSN: 1076-1551, DOI: 10.1186/s10020-019-0090-5
KRISHNAN DHANYA; MENON RAMSEKHAR N.; MATHURANATH PAVAGADA SIVASANKARA; GOPALA SRINIVAS: "A novel role for SHARPIN in amyloid-β phagocytosis and inflammation by peripheral blood-derived macrophages in Alzheimer's disease", NEUROBIOLOGY OF AGING, vol. 93, 13 February 2020 (2020-02-13), US , pages 131 - 141, XP086187175, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2020.02.001
SOHEILI‐NEZHAD SOURENA, JAHANSHAD NEDA, GUELFI SEBASTIAN, KHOSROWABADI REZA, SAYKIN ANDREW J., THOMPSON PAUL M., BECKMANN CHRISTIA: "Imaging genomics discovery of a new risk variant for Alzheimer's disease in the postsynaptic SHARPIN gene ", HUMAN BRAIN MAPPING, vol. 41, no. 13, 1 September 2020 (2020-09-01), pages 3737 - 3748, XP055933581, ISSN: 1065-9471, DOI: 10.1002/hbm.25083
ASANOMI YUYA, SHIGEMIZU DAICHI, MIYASHITA AKINORI, MITSUMORI RISA, MORI TAIKI, HARA NORIKAZU, ITO KAORU, NIIDA SHUMPEI, IKEUCHI TA: "A rare functional variant of SHARPIN attenuates the inflammatory response and associates with increased risk of late-onset Alzheimer’s disease", MOLECULAR MEDICINE, vol. 25, no. 20, 1 December 2019 (2019-12-01), Washington , DC , pages 1 - 9, XP055933559, ISSN: 1076-1551, DOI: 10.1186/s10020-019-0090-5
KRISHNAN DHANYA; MENON RAMSEKHAR N.; MATHURANATH PAVAGADA SIVASANKARA; GOPALA SRINIVAS: "A novel role for SHARPIN in amyloid-β phagocytosis and inflammation by peripheral blood-derived macrophages in Alzheimer's disease", NEUROBIOLOGY OF AGING, vol. 93, 13 February 2020 (2020-02-13), US , pages 131 - 141, XP086187175, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2020.02.001
SOHEILI‐NEZHAD SOURENA, JAHANSHAD NEDA, GUELFI SEBASTIAN, KHOSROWABADI REZA, SAYKIN ANDREW J., THOMPSON PAUL M., BECKMANN CHRISTIA: "Imaging genomics discovery of a new risk variant for Alzheimer's disease in the postsynaptic SHARPIN gene ", HUMAN BRAIN MAPPING, vol. 41, no. 13, 1 September 2020 (2020-09-01), pages 3737 - 3748, XP055933581, ISSN: 1065-9471, DOI: 10.1002/hbm.25083
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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