Title:
SINGLE NUCLEOTIDE POLYMORPHISM FOR THE PROGNOSIS OF HEPATOCELLULAR CARCINOMA
Document Type and Number:
WIPO Patent Application WO/2011/118967
Kind Code:
A2
Abstract:
The present invention relates to a single nucleotide polymorphism (SNP) for the prognosis of hepatocellular carcinoma, wherein the SNP shows a significant correlation with an over-expression of MTA1 which is a useful prognostic factor for prediction of recurrence or poor survival after hepatocellular carcinoma surgery. Therefore, the SNP can be used in developing micro-arrays or diagnosis kits for the prognosis of hepatocellular carcinoma, and in screening drugs for improving prognosis of hepatocellular carcinoma to thereby improve poor prognosis of hepatocellular carcinoma after surgery.
Inventors:
CHUNG YOUNG-HWA (KR)
PARK NUNG-HUA (KR)
YU EUN-SIL (KR)
LEE YOUNG-JOO (KR)
KIM JEONG-A (KR)
LEE DAN-BI (KR)
LEE SAE-HWAN (KR)
LEE JONG-EUN (KR)
PARK NUNG-HUA (KR)
YU EUN-SIL (KR)
LEE YOUNG-JOO (KR)
KIM JEONG-A (KR)
LEE DAN-BI (KR)
LEE SAE-HWAN (KR)
LEE JONG-EUN (KR)
Application Number:
PCT/KR2011/001964
Publication Date:
September 29, 2011
Filing Date:
March 22, 2011
Export Citation:
Assignee:
UNIV ULSAN FOUND FOR IND COOP (KR)
CHUNG YOUNG-HWA (KR)
PARK NUNG-HUA (KR)
YU EUN-SIL (KR)
LEE YOUNG-JOO (KR)
KIM JEONG-A (KR)
LEE DAN-BI (KR)
LEE SAE-HWAN (KR)
LEE JONG-EUN (KR)
CHUNG YOUNG-HWA (KR)
PARK NUNG-HUA (KR)
YU EUN-SIL (KR)
LEE YOUNG-JOO (KR)
KIM JEONG-A (KR)
LEE DAN-BI (KR)
LEE SAE-HWAN (KR)
LEE JONG-EUN (KR)
International Classes:
C12Q1/68; C12N15/11; G01N33/15
Other References:
DATABASE DBSNP [Online] 19 July 2005 Database accession no. rs11938826
DATABASE DBSNP [Online] 19 July 2005 Database accession no. rs308395
DATABASE DBSNP [Online] 04 October 2000 Database accession no. rs308428
DATABASE DBSNP [Online] 30 November 2007 Database accession no. rs3741208
KIM, Y. J. ET AL.: 'IGF2 polymorphisms are associated with hepatitis B virus clearance and hepatocellular carcinoma' BIOCHEM. BIOPHYS. RES. COMMUN. vol. 346, no. 1, 21 July 2006, pages 38 - 44
TAKEDA, S.: 'Allelic-expression imbalance of the insulin-like growth factor 2 gene in hepatocellular carcinoma and underlying disease' ONCOGENE vol. 12, no. 7, 04 April 1996, pages 1589 - 1592
DATABASE DBSNP [Online] 19 July 2005 Database accession no. rs308395
DATABASE DBSNP [Online] 04 October 2000 Database accession no. rs308428
DATABASE DBSNP [Online] 30 November 2007 Database accession no. rs3741208
KIM, Y. J. ET AL.: 'IGF2 polymorphisms are associated with hepatitis B virus clearance and hepatocellular carcinoma' BIOCHEM. BIOPHYS. RES. COMMUN. vol. 346, no. 1, 21 July 2006, pages 38 - 44
TAKEDA, S.: 'Allelic-expression imbalance of the insulin-like growth factor 2 gene in hepatocellular carcinoma and underlying disease' ONCOGENE vol. 12, no. 7, 04 April 1996, pages 1589 - 1592
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
특허법인 태백 (KR)
특허법인 태백 (KR)
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Claims: