Title:
SINGLE-STRANDED NUCLEIC ACID MOLECULE HAVING AMINO ACID BACKBONE
Document Type and Number:
WIPO Patent Application WO/2013/103146
Kind Code:
A1
Abstract:
The purpose of the invention is to provide a novel nucleic acid molecule that can be produced easily and efficiently and makes it possible to suppress the expression of a gene. A single-stranded nucleic acid molecule containing an expression suppression sequence for suppressing the expression of a target gene, the molecule being characterized by containing a region (X), linker region (Lx), and region (Xc). The linker region (Lx) is connected between the region (Xc) and the region (X), the region (Xc) is complementary with the region (X), the region (X) and/or the region (Xc) contains the expression suppression sequence, and the linker region (Lx) contains an atomic group derived from an amino acid. The single-stranded nucleic acid molecule makes it possible to suppress the expression of the target gene.
Inventors:
OHGI TADAAKI (JP)
SUZUKI HIROSHI (JP)
HAMASAKI TOMOHIRO (JP)
AOKI ERIKO (JP)
SUZUKI HIROSHI (JP)
HAMASAKI TOMOHIRO (JP)
AOKI ERIKO (JP)
Application Number:
PCT/JP2012/084247
Publication Date:
July 11, 2013
Filing Date:
December 29, 2012
Export Citation:
Assignee:
BONAC CORP (JP)
International Classes:
C12N15/113; A61K48/00; C07C225/06
Domestic Patent References:
| WO2009076321A2 | 2009-06-18 | |||
| WO2005030960A1 | 2005-04-07 | |||
| WO2004015075A2 | 2004-02-19 |
Foreign References:
| JP2008526213A | 2008-07-24 | |||
| JP2011504730A | 2011-02-17 | |||
| JP2007516695A | 2007-06-28 | |||
| JP2005508634A | 2005-04-07 | |||
| JP2004524032A | 2004-08-12 | |||
| US20040058886A1 | 2004-03-25 | |||
| US3687808A | 1972-08-29 | |||
| US20040007070W | 2004-03-08 | |||
| US6509323B1 | 2003-01-21 | |||
| US20030008818A1 | 2003-01-09 |
Other References:
ABE, NAOKO ET AL.: "Synthesis, structure, and biological activity of dumbbell-shaped nanocircular RNAs for RNA interference", BIOCONJUG. CHEM., vol. 22, 2011, pages 2082 - 2092, XP055075533
DE LA TORRE, BEATRIZ G. ET AL.: "Synthesis of Oligonucleotides Carrying Anchoring Groups and Their Use in the Preparation of Oligonucleotide-Gold Conjugates", HELVETICA CHIMICA ACTA, vol. 85, 2002, pages 2594 - 2607, XP055154708
FIRE ET AL., NATURE, vol. 391, no. 6669, 19 February 1998 (1998-02-19), pages 806 - 11
J. F. W. MCOMIE: "Protecting Groups in Organic Chemistry", 1973, PLENUM PRESS
LIMBACH ET AL.: "Summary: the modified nucleosides of RNA", NUCLEIC ACIDS RES., vol. 22, 1994, pages 2183 - 2196, XP001152667
KROSCHWITZ J. I,: "Concise Encyclopedia of Polymer Science and Engineering", 1990, JOHN WILEY & SONS, pages: 858 - 859
ENGLISCH ET AL., ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 30, 1991, pages 613
See also references of EP 2801617A4
DE LA TORRE, BEATRIZ G. ET AL.: "Synthesis of Oligonucleotides Carrying Anchoring Groups and Their Use in the Preparation of Oligonucleotide-Gold Conjugates", HELVETICA CHIMICA ACTA, vol. 85, 2002, pages 2594 - 2607, XP055154708
FIRE ET AL., NATURE, vol. 391, no. 6669, 19 February 1998 (1998-02-19), pages 806 - 11
J. F. W. MCOMIE: "Protecting Groups in Organic Chemistry", 1973, PLENUM PRESS
LIMBACH ET AL.: "Summary: the modified nucleosides of RNA", NUCLEIC ACIDS RES., vol. 22, 1994, pages 2183 - 2196, XP001152667
KROSCHWITZ J. I,: "Concise Encyclopedia of Polymer Science and Engineering", 1990, JOHN WILEY & SONS, pages: 858 - 859
ENGLISCH ET AL., ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 30, 1991, pages 613
See also references of EP 2801617A4
Attorney, Agent or Firm:
TSUJIMARU Koichiro et al. (JP)
Koichiro Tsujimaru (JP)
Koichiro Tsujimaru (JP)
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