Title:
SIRNA HAVING ANTIVIRAL ACTIVITY AGAINST BOTH ENTEROVIRUS 70 AND COXSACKIEVIRUS A24, AND PHARMACEUTICAL COMPOSITION FOR TREATING AND PREVENTING ACUTE HEMORRHAGIC CONJUNCTIVITIS CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2011/090307
Kind Code:
A3
Abstract:
The present invention relates to siRNA having antiviral activity against both enterovirus 70 and coxsackievirus A24, wherein said siRNA exhibits remarkably superior antiviral activity by significantly inhibiting cytotoxicity and viral replication in both enterovirus 70 and coxsackievirus A24, which are the main causes of acute hemorrhagic conjunctivitis, and thus can be used effectively as antiviral agents, in particular as therapeutic agents for acute hemorrhagic conjunctivitis.
Inventors:
LEE HEUI-RAN (KR)
JUN EUN-JUNG (KR)
KO A-RA (KR)
KIM YOO-KYUM (KR)
TCHAH HUNG-WON (KR)
AHN JEONG-HYUN (KR)
WON MIN-AH (KR)
JUN EUN-JUNG (KR)
KO A-RA (KR)
KIM YOO-KYUM (KR)
TCHAH HUNG-WON (KR)
AHN JEONG-HYUN (KR)
WON MIN-AH (KR)
Application Number:
PCT/KR2011/000372
Publication Date:
December 29, 2011
Filing Date:
January 19, 2011
Export Citation:
Assignee:
UNIV ULSAN FOUND FOR IND COOP (KR)
LEE HEUI-RAN (KR)
JUN EUN-JUNG (KR)
KO A-RA (KR)
KIM YOO-KYUM (KR)
TCHAH HUNG-WON (KR)
AHN JEONG-HYUN (KR)
WON MIN-AH (KR)
LEE HEUI-RAN (KR)
JUN EUN-JUNG (KR)
KO A-RA (KR)
KIM YOO-KYUM (KR)
TCHAH HUNG-WON (KR)
AHN JEONG-HYUN (KR)
WON MIN-AH (KR)
International Classes:
A61K31/7105; A61P31/12
Foreign References:
| KR20090020244A | 2009-02-26 | |||
| KR20050084693A | 2005-08-26 |
Other References:
JUN, E.J. ET AL.: "Antiviral potency of a siRNA targeting a conserved region of coxsackievirus A24", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 376, 2008, pages 389 - 394, XP025495745, DOI: doi:10.1016/j.bbrc.2008.08.169
LEE, H.S. ET AL.: "Universal and mutation-resistant anti-enteroviral activity: Potency of small interfering RNA complementary to the conserved cis-acting replication element within the enterovirus coding region", J. GENERAL VIROLOGY, vol. 88, 2007, pages 2003 - 2012
LEE, H.S. ET AL.: "Universal and mutation-resistant anti-enteroviral activity: Potency of small interfering RNA complementary to the conserved cis-acting replication element within the enterovirus coding region", J. GENERAL VIROLOGY, vol. 88, 2007, pages 2003 - 2012
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (Kolontechnovalley60-4 Gasan-dong, Geumcheon-gu, Seoul 153-770, KR)
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