Title:
SIRTUIN OR KLOTHO ACTIVATOR OR EXPRESSION ENHANCER, NAD+ INCREASING AGENT, AND SENOLYTIC AGENT
Document Type and Number:
WIPO Patent Application WO/2022/220265
Kind Code:
A1
Abstract:
Provided is a novel use of S-1-propenylcysteine, a salt thereof or a composition containing the same. A Sirtuin or Klotho activator or expression enhancer that comprises S-1-propenylcysteine or a salt thereof as an active ingredient.
Inventors:
SUZUKI JUNICHIRO (JP)
FUJII KAYO (JP)
TAKASHIMA MIYUKI (JP)
MIKI SATOMI (JP)
USHIJIMA MITSUYASU (JP)
MATSUTOMO TOSHIAKI (JP)
FUJII KAYO (JP)
TAKASHIMA MIYUKI (JP)
MIKI SATOMI (JP)
USHIJIMA MITSUYASU (JP)
MATSUTOMO TOSHIAKI (JP)
Application Number:
PCT/JP2022/017713
Publication Date:
October 20, 2022
Filing Date:
April 13, 2022
Export Citation:
Assignee:
WAKUNAGA PHARMA CO LTD (JP)
International Classes:
A61K31/198; A23L33/105; A61P3/02; A61P13/12; A61P17/00; A61P25/18; A61P43/00
Domestic Patent References:
| WO2016199885A1 | 2016-12-15 | |||
| WO2016088892A1 | 2016-06-09 | |||
| WO2016088892A1 | 2016-06-09 | |||
| WO2016199885A1 | 2016-12-15 | |||
| WO2019031442A1 | 2019-02-14 | |||
| WO2019235597A1 | 2019-12-12 | |||
| WO2020230813A1 | 2020-11-19 |
Foreign References:
| KR20170115346A | 2017-10-17 | |||
| CN105943804A | 2016-09-21 | |||
| JP2020029529A | 2020-02-27 | |||
| JP2020029529A | 2020-02-27 | |||
| JP6105871B2 | 2017-03-29 | |||
| JP2015144571A | 2015-08-13 |
Other References:
ZAHRA ARAB SADEGHABADI , NASRIN ZIAMAJIDI, ROGHAYEH ABBASALIPOURKABIR, ROOHOLLAH MOHSENI: "Garlic (Allium sativum) increases SIRT1 and SIRT2 gene expressions in the kidney and liver tissues of STZ- and STZ+niacinamide-induced diabetic rats", JOURNAL OF BASIC AND CLINICAL PHYSIOLOGY AND PHARMACOLOGY, vol. 29, no. 5, 19 April 2018 (2018-04-19), GB , pages 463 - 467, XP009540302, ISSN: 0792-6855, DOI: 10.1515/jbcpp-2017-0079
LIN ZHONG , FEI HUANG , HAILIAN SHI , HUI WU , BEIBEI ZHANG , XIAOJUN WU , XIAOHUI WEI , ZHENGTAO WANG: "Qing'E formula alleviates the aging process in D-galactose-induced aging mice", BIOMEDICAL REPORTS, pages 101 - 106, XP055976634, DOI: 10.3892/br.2016.667
TORU MORIGUCHI, HIROSHI SAITO, NOBUYOSHI NISHIYAMA: "Aged Garlic Extract Prolongs Longevity and Improves Spatial Memory Deficit in Senescence-Accelerated Mouse", BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 19, no. 2, 1 February 1996 (1996-02-01), JP , pages 305 - 307, XP008056754, ISSN: 0918-6158, DOI: 10.1248/bpb.19.305
GALAL HEBA M.; ABD EL-RADY NESSREN M.: "Aqueous garlic extract supresses experimental gentamicin induced renal pathophysiology mediated by oxidative stress, inflammation and Kim-1", PATHOPHYSIOLOGY, vol. 26, no. 3, 29 July 2019 (2019-07-29), NL , pages 271 - 279, XP086016068, ISSN: 0928-4680, DOI: 10.1016/j.pathophys.2019.07.002
YUKIHIORO KODERA, USHIJIMA MITSUYASU, AMANO HIROTAKA, SUZUKI JUN-ICHIRO, MATSUTOMO TOSHIAKI: "Chemical and Biological Properties of S-1-Propenyl-ʟ-Cysteine in Aged Garlic Extract", MOLECULES, vol. 22, no. 4, 31 March 2017 (2017-03-31), pages 1 - 18, XP055576029, DOI: 10.3390/molecules22040570
MICHIYASU SUGII , YUJI SUZUKI , SHIGEHARU NAGASAWA: "Isolation of (-) S-Propenyl-L-cysteine from Garlic", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 11, no. 4, 26 April 1963 (1963-04-26), pages 548 - 549, XP055976643, ISSN: 0009-2363, DOI: 10.1248/cpb.11.548
MASAKI IGARASHI: "NAD+ metabolism, sirtuins and stem cell aging", BIOCHEMISTRY, vol. 89, no. 4, 25 August 2017 (2017-08-25), JP , pages 555 - 558, XP009540303, ISSN: 0037-1017, DOI: 10.14952/SEIKAGAKU.2017.890555
USHIJIMA MITSUYASU, KUNIMURA KAYO, SUZUKI JUN‑ICHIRO: "S‑1‑Propenylcysteine, a sulfur compound in aged garlic extract, alleviates cold‑induced reduction in peripheral blood flow in rat via activation of the AMPK/eNOS/NO pathway", EXPERIMENTAL AND THERAPEUTIC MEDICINE, vol. 20, no. 3, 20 September 2020 (2020-09-20), GR , pages 2815 - 2821, XP055976647, ISSN: 1792-0981, DOI: 10.3892/etm.2020.8969
SURAJIT PATHAK , ROBERTO CATANZARO,DHARANI VASAN,FRANCESCO MAROTTA,YASHNA CHABRIA ,GANESAN JOTHIMANI , RAMA SHANKER VERMA: "Benefits of aged garlic extract in modulating toxicity biomarkers against p-dimethylaminoazobenzene and phenobarbital induced liver damage in Rattus norvegicus", DRUG AND CHEMICAL TOXICOLOGY, vol. 43, no. 5, 1 January 2020 (2020-01-01), US , pages 454 - 467, XP009540308, ISSN: 0148-0545, DOI: 10.1080/01480545.2018.1499773
TRENDS CELL BIOL., vol. 24, no. 8, 2014, pages 464 - 71
J NEUROSCI, vol. 30, no. 29, 2010, pages 9695 - 9707
CELL METAB., vol. 27, no. 3, 6 March 2018 (2018-03-06), pages 513 - 528
BMC NEPHROL, vol. 19, 2018, pages 285
NATURE, vol. 479, no. 7372, 2 November 2011 (2011-11-02), pages 232 - 6
FRONT PHARMACOL, vol. 10, 2019, pages 770
TETRAHEDRON LETTER, vol. 37, 1975, pages 3201 - 3202
SYNTHESIS, vol. 20, 2006, pages 3367 - 3369
BULL. KOREAN CHEM. SOC., vol. 32, no. 1, 2011, pages 319 - 320
MOLECULES, vol. 22, 2017, pages 570
THE JOURNAL OF TOXICOLOGICAL SCIENCES, vol. 9, 1984, pages 57
FRONT PLANT SCI, vol. 9, 5 July 2018 (2018-07-05), pages 961
LIN ZHONG , FEI HUANG , HAILIAN SHI , HUI WU , BEIBEI ZHANG , XIAOJUN WU , XIAOHUI WEI , ZHENGTAO WANG: "Qing'E formula alleviates the aging process in D-galactose-induced aging mice", BIOMEDICAL REPORTS, pages 101 - 106, XP055976634, DOI: 10.3892/br.2016.667
TORU MORIGUCHI, HIROSHI SAITO, NOBUYOSHI NISHIYAMA: "Aged Garlic Extract Prolongs Longevity and Improves Spatial Memory Deficit in Senescence-Accelerated Mouse", BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 19, no. 2, 1 February 1996 (1996-02-01), JP , pages 305 - 307, XP008056754, ISSN: 0918-6158, DOI: 10.1248/bpb.19.305
GALAL HEBA M.; ABD EL-RADY NESSREN M.: "Aqueous garlic extract supresses experimental gentamicin induced renal pathophysiology mediated by oxidative stress, inflammation and Kim-1", PATHOPHYSIOLOGY, vol. 26, no. 3, 29 July 2019 (2019-07-29), NL , pages 271 - 279, XP086016068, ISSN: 0928-4680, DOI: 10.1016/j.pathophys.2019.07.002
YUKIHIORO KODERA, USHIJIMA MITSUYASU, AMANO HIROTAKA, SUZUKI JUN-ICHIRO, MATSUTOMO TOSHIAKI: "Chemical and Biological Properties of S-1-Propenyl-ʟ-Cysteine in Aged Garlic Extract", MOLECULES, vol. 22, no. 4, 31 March 2017 (2017-03-31), pages 1 - 18, XP055576029, DOI: 10.3390/molecules22040570
MICHIYASU SUGII , YUJI SUZUKI , SHIGEHARU NAGASAWA: "Isolation of (-) S-Propenyl-L-cysteine from Garlic", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 11, no. 4, 26 April 1963 (1963-04-26), pages 548 - 549, XP055976643, ISSN: 0009-2363, DOI: 10.1248/cpb.11.548
MASAKI IGARASHI: "NAD+ metabolism, sirtuins and stem cell aging", BIOCHEMISTRY, vol. 89, no. 4, 25 August 2017 (2017-08-25), JP , pages 555 - 558, XP009540303, ISSN: 0037-1017, DOI: 10.14952/SEIKAGAKU.2017.890555
USHIJIMA MITSUYASU, KUNIMURA KAYO, SUZUKI JUN‑ICHIRO: "S‑1‑Propenylcysteine, a sulfur compound in aged garlic extract, alleviates cold‑induced reduction in peripheral blood flow in rat via activation of the AMPK/eNOS/NO pathway", EXPERIMENTAL AND THERAPEUTIC MEDICINE, vol. 20, no. 3, 20 September 2020 (2020-09-20), GR , pages 2815 - 2821, XP055976647, ISSN: 1792-0981, DOI: 10.3892/etm.2020.8969
SURAJIT PATHAK , ROBERTO CATANZARO,DHARANI VASAN,FRANCESCO MAROTTA,YASHNA CHABRIA ,GANESAN JOTHIMANI , RAMA SHANKER VERMA: "Benefits of aged garlic extract in modulating toxicity biomarkers against p-dimethylaminoazobenzene and phenobarbital induced liver damage in Rattus norvegicus", DRUG AND CHEMICAL TOXICOLOGY, vol. 43, no. 5, 1 January 2020 (2020-01-01), US , pages 454 - 467, XP009540308, ISSN: 0148-0545, DOI: 10.1080/01480545.2018.1499773
TRENDS CELL BIOL., vol. 24, no. 8, 2014, pages 464 - 71
J NEUROSCI, vol. 30, no. 29, 2010, pages 9695 - 9707
CELL METAB., vol. 27, no. 3, 6 March 2018 (2018-03-06), pages 513 - 528
BMC NEPHROL, vol. 19, 2018, pages 285
NATURE, vol. 479, no. 7372, 2 November 2011 (2011-11-02), pages 232 - 6
FRONT PHARMACOL, vol. 10, 2019, pages 770
TETRAHEDRON LETTER, vol. 37, 1975, pages 3201 - 3202
SYNTHESIS, vol. 20, 2006, pages 3367 - 3369
BULL. KOREAN CHEM. SOC., vol. 32, no. 1, 2011, pages 319 - 320
MOLECULES, vol. 22, 2017, pages 570
THE JOURNAL OF TOXICOLOGICAL SCIENCES, vol. 9, 1984, pages 57
FRONT PLANT SCI, vol. 9, 5 July 2018 (2018-07-05), pages 961
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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