Title:
SITE-SPECIFIC ANTIBODY CONJUGATES AND THE METHODS FOR PREPARATION OF THE SAME
Document Type and Number:
WIPO Patent Application WO/2022/037665
Kind Code:
A1
Abstract:
The present disclosure provides a site-specific protein conjugate and the method for preparation of the same. The protein conjugate comprising a protein and an oligosaccharide, wherein said oligosaccharide comprises (I) wherein: said GlcNAc is directly or indirectly linked to an amino acid of said protein; said Gal is a galactose; said (Fuc) is a fucose, b is 0 or 1; said Fuc* comprises a fucose or a fucose derivative linked to a molecule of interest (MOI), said protein comprises an antigen binding fragment and/or a Fc fragment.
Inventors:
YANG YI (CN)
Application Number:
PCT/CN2021/113692
Publication Date:
February 24, 2022
Filing Date:
August 20, 2021
Export Citation:
Assignee:
GLYCO THERAPY BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07K9/00; A61K38/00; A61K39/395; A61P35/00; C07K14/00; C07K16/00
Other References:
WU ZHENGLIANG L, WHITTAKER MARK, ERTELT JAMES M, PERSON ANTHONY D, KALABOKIS VASSILI: "Detecting substrate glycans of fucosyltransferases with fluorophore-conjugated fucose and methods for glycan electrophoresis", GLYCOBIOLOGY, vol. 30, no. 12, 9 December 2020 (2020-12-09), pages 970 - 980, XP055773802, DOI: 10.1093/glycob/cwaa030
BOUNE SOUAD, HU PEISHENG, EPSTEIN ALAN L., KHAWLI LESLIE A.: "Principles of N-Linked Glycosylation Variations of IgG-Based Therapeutics: Pharmacokinetic and Functional Considerations", ANTIBODIES, vol. 9, no. 2, 10 June 2020 (2020-06-10), CH , pages 22, XP055786980, ISSN: 2073-4468, DOI: 10.3390/antib9020022
BOUNE SOUAD, HU PEISHENG, EPSTEIN ALAN L., KHAWLI LESLIE A.: "Principles of N-Linked Glycosylation Variations of IgG-Based Therapeutics: Pharmacokinetic and Functional Considerations", ANTIBODIES, vol. 9, no. 2, 10 June 2020 (2020-06-10), CH , pages 22, XP055786980, ISSN: 2073-4468, DOI: 10.3390/antib9020022
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
Download PDF:
Previous Patent: DISCONTINUOUS RECEPTION (DRX) CONFIGURATION METHOD AND APPARATUS, AND DEVICE
Next Patent: APPLICATION OF RDR PROTEIN IN TUMOR THERAPY
Next Patent: APPLICATION OF RDR PROTEIN IN TUMOR THERAPY