Title:
SITE-SPECIFIC GLYCOPROTEIN CONJUGATES AND METHODS FOR MAKING THE SAME
Document Type and Number:
WIPO Patent Application WO/2023/065137
Kind Code:
A1
Abstract:
The present disclosure provides a protein conjugate, comprising a protein and an oligosaccharide, wherein the oligosaccharide comprises Formula (1) : wherein, the GlcNAc is directly or indirectly linked to an amino acid of the protein, the GalX is a substituted galactose, the Fuc in parentheses is a fucose, and b is 0 or 1, the Fuc* comprises a fucose or fucose derivative (Fuco) and a molecule of interest (MOI1). The present disclosure also provides a method for making the protein conjugate and the use of the protein conjugate in disease treatment.
Inventors:
YANG YI (CN)
SONG ZHENTAO (CN)
CHEN JI (CN)
SONG ZHENTAO (CN)
CHEN JI (CN)
Application Number:
PCT/CN2021/124891
Publication Date:
April 27, 2023
Filing Date:
October 20, 2021
Export Citation:
Assignee:
GLYCO THERAPY BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07K9/00; A61K38/00; A61K39/395; A61P35/00; C07K14/00; C07K16/00
Domestic Patent References:
| WO2017137457A1 | 2017-08-17 | |||
| WO2014065661A1 | 2014-05-01 |
Foreign References:
| US20110177029A1 | 2011-07-21 |
Other References:
ZHENGLIANG L WU，ET AL: "Detecting substrate glycans of fucosyltransferases with fluorophore-conjugated fucose and methods for glycan electrophoresis", GLYCOBIOLOGY, vol. 30, no. 12, 9 December 2020 (2020-12-09), XP055773802, DOI: 10.1093/glycob/cwaa030
SOUAD BOUNE, ET AL: "Principles of -inked Glycosylation Variations of Igg-based TherapeuticPharmacokinetic and Functional Considerations", ANTIBODIES, vol. 2, no. 9, 10 June 2020 (2020-06-10), pages 3 - 16, XP055786980
SOUAD BOUNE, ET AL: "Principles of -inked Glycosylation Variations of Igg-based TherapeuticPharmacokinetic and Functional Considerations", ANTIBODIES, vol. 2, no. 9, 10 June 2020 (2020-06-10), pages 3 - 16, XP055786980
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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