Title:
SIX-MEMBERED HETEROCYCLIC COMPOUND AND THE USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2006/080323
Kind Code:
A1
Abstract:
A compound that can be used as a pharmaceutical active ingredient effective in prevention and/or treatment of osteoporosis, a bone disease such as fracture, and further, glaucoma or ulcerative colitis, and is represented by the general formula (I): [Chemical formula 1] (I) [wherein T represents an oxygen atom or the like; V represents CH2 or the like; R01 to R04 represent a hydrogen atom or the like; A represents a linear alkylene group or a linear alkenylene group having 2 to 8 carbon atoms or the like; D represents a carboxyl group or the like; X represents an ethylene group, a trimethylene group or the like; E represents a -CH(OH)- group or the like; and W represents a -U1-(RW1)(RW2)-U2-U3 group (wherein U1 represents a single bond or an alkylene group having 1 to 4 carbon atoms or the like; RW1 and RW2 represent a hydrogen atom or the like; U2 represents a single bond, an alkylene group having 1 to 4 carbon atoms or the like; and U3 represents an alkyl group having 1 to 8 carbon atoms or the like) or a residue of a carbocyclic or heterocyclic compound]; or a salt thereof.
Inventors:
SHODA MOTOSHI (JP)
ISHIZUYA TOSHINORI (JP)
ISHIZUYA TOSHINORI (JP)
Application Number:
PCT/JP2006/301093
Publication Date:
August 03, 2006
Filing Date:
January 25, 2006
Export Citation:
Assignee:
ASAHI KASEI PHARMA CORP (JP)
SHODA MOTOSHI (JP)
ISHIZUYA TOSHINORI (JP)
SHODA MOTOSHI (JP)
ISHIZUYA TOSHINORI (JP)
International Classes:
C07D237/04; A61K31/50; A61P1/02; A61P19/00; A61P19/02; A61P19/08; A61P19/10; A61P29/00; A61P43/00
Domestic Patent References:
| WO2004085430A1 | 2004-10-07 | |||
| WO2003035064A1 | 2003-05-01 | |||
| WO2004063158A1 | 2004-07-29 |
Other References:
ALVAREZ-IBARRA C. ET AL.: "Diastereoselective Synthesis and Estimation of the Conformational Flexibility of 6-Oxoperhydropyridazine-3-carboxylic Acid Derivatives", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 67, no. 9, 3 May 2002 (2002-05-03), pages 2789 - 2797, XP002998008
HITCHCOCK S.R. ET AL.: "Intramolecular Chiral Relay at Stereogenic Nitrogen. Synthesis and Application of a New Chiral Auxiliary Derived from (1R,2S)-Norephedrine and Acetone", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 69, no. 3, 6 February 2004 (2004-02-06), pages 714 - 718, XP002998009
HITCHCOCK S.R. ET AL.: "Intramolecular Chiral Relay at Stereogenic Nitrogen. Synthesis and Application of a New Chiral Auxiliary Derived from (1R,2S)-Norephedrine and Acetone", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 69, no. 3, 6 February 2004 (2004-02-06), pages 714 - 718, XP002998009
Attorney, Agent or Firm:
SIKs & Co. (Kyobashi-Nisshoku Bldg. 8-7, Kyobashi 1-chom, Chuo-ku Tokyo, JP)
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