Title:
SKIN IRRITATION SUPPRESSANT AND TRANSDERMAL PREPARATION
Document Type and Number:
WIPO Patent Application WO/2011/136283
Kind Code:
A1
Abstract:
Provided is a skin irritation suppressant for transdermal preparations, said skin irritation suppressant having an acknowledged effect of adequately reducing skin irritation caused by drugs. Also provided is a transdermal preparation containing said skin irritation suppressant. One embodiment of the invention is a skin irritation suppressant for reducing skin irritation caused by pharmaceutical adjuvants used in drugs and transdermal preparations other than drugs, said skin irritation suppressant comprising sterol compounds selected from a group comprising cholesterol, cholesterol derivatives and cholesterol analogs. Said drug is one or more basic drugs selected from a group comprising tolterodine, asenapine, bisoprolol, risperidone, nicotine, and mitalopram, and pharmacologically acceptable salts thereof.
Inventors:
KUMA HIDEKAZU (JP)
ATARASHI KENJI (JP)
SUZUKI KAZUHIRO (JP)
AIDA KAZUNOSUKE (JP)
ATARASHI KENJI (JP)
SUZUKI KAZUHIRO (JP)
AIDA KAZUNOSUKE (JP)
Application Number:
PCT/JP2011/060290
Publication Date:
November 03, 2011
Filing Date:
April 27, 2011
Export Citation:
Assignee:
HISAMITSU PHARMACEUTICAL CO (JP)
KUMA HIDEKAZU (JP)
ATARASHI KENJI (JP)
SUZUKI KAZUHIRO (JP)
AIDA KAZUNOSUKE (JP)
KUMA HIDEKAZU (JP)
ATARASHI KENJI (JP)
SUZUKI KAZUHIRO (JP)
AIDA KAZUNOSUKE (JP)
International Classes:
A61K47/10; A61K9/70; A61K31/137; A61K31/138; A61K31/343; A61K31/407; A61K31/465; A61K31/517
Domestic Patent References:
| WO2008044336A1 | 2008-04-17 | |||
| WO2006082888A1 | 2006-08-10 | |||
| WO2009075258A1 | 2009-06-18 |
Foreign References:
| JP2002265346A | 2002-09-18 | |||
| JP2007284378A | 2007-11-01 | |||
| JP2007045738A | 2007-02-22 | |||
| JPH04501415A | 1992-03-12 |
Other References:
YASUKAWA, K. ET AL.: "Inhibitory Effects of Sterols Isolated from Chlorella vulgaris on 12-0-Tetradecanoylphorbol-13-acetate-Induced Inflammation and Tumor Promotion in Mouse Skin.", BIOL PHARM BULL, vol. 19, no. 4, 1996, pages 573 - 576, XP001026394
ICHIRO KATAYAMA ET AL.: "Jusho Atopic Dermatitis no Nanjika Kijo o Fumaeta Chiryoho no Kakuritsu ni Kansuru Kenkyu Lipid Raft o Hyoteki to shita Atarashii Allergic Disease Chiryo Senryaku no Kento", JUSHO ATOPIC DERMATITIS NO NANJIKA KIJO O FUMAETA CHIRYOHO NO KAKURITSU NI KANSURU KENKYU HEISEI 15 TO 17 NENDO SOGO KENKYU HOKOKUSHO, 2006, pages 63 - 68
KASAHARA Y. ET AL.: "Carthami Flos extract and its component, stigmasterol, inhibit tumor promotion in mouse skin two-stage carcinogenesis", PHYTOTHERAPY RESEARCH, vol. 8, no. 6, 1994, pages 327 - 331, XP009085140
KAMINAGA T. ET AL.: "Inhibitory effect of Poria cocos on 12-O-tetradecanoylphorbol-13- acetate-induced ear edema and tumor promotion in mouse skin", PHYTOTHERAPY RESEARCH, vol. 10, no. 7, 1996, pages 581 - 584, XP055069399
See also references of EP 2564873A4
DRAIZE JH ET AL., J PHARMACOL EXP THER., vol. 82, 1944, pages 377 - 390
ICHIRO KATAYAMA ET AL.: "Jusho Atopic Dermatitis no Nanjika Kijo o Fumaeta Chiryoho no Kakuritsu ni Kansuru Kenkyu Lipid Raft o Hyoteki to shita Atarashii Allergic Disease Chiryo Senryaku no Kento", JUSHO ATOPIC DERMATITIS NO NANJIKA KIJO O FUMAETA CHIRYOHO NO KAKURITSU NI KANSURU KENKYU HEISEI 15 TO 17 NENDO SOGO KENKYU HOKOKUSHO, 2006, pages 63 - 68
KASAHARA Y. ET AL.: "Carthami Flos extract and its component, stigmasterol, inhibit tumor promotion in mouse skin two-stage carcinogenesis", PHYTOTHERAPY RESEARCH, vol. 8, no. 6, 1994, pages 327 - 331, XP009085140
KAMINAGA T. ET AL.: "Inhibitory effect of Poria cocos on 12-O-tetradecanoylphorbol-13- acetate-induced ear edema and tumor promotion in mouse skin", PHYTOTHERAPY RESEARCH, vol. 10, no. 7, 1996, pages 581 - 584, XP055069399
See also references of EP 2564873A4
DRAIZE JH ET AL., J PHARMACOL EXP THER., vol. 82, 1944, pages 377 - 390
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
Yoshiki Hasegawa (JP)
Yoshiki Hasegawa (JP)
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