Title:
SKIN WHITENING AGENT
Document Type and Number:
WIPO Patent Application WO/2018/173816
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a skin whitening agent that is effective for preventing or inhibiting melanin pigmentation, such as pigmented spots, flecks, and dullness in the skin. More specifically, the present invention provides: a skin whitening agent that contains at least one type of a D-amino acid selected from the group consisting of D-asparagine, D-valine, D-allo-threonine, D-lysine, D-glutamine, D-histidine, D-leucine, D-phenylalanine, D-serine, D-tryptophan, and D-tyrosine; and a method for making an assessment of skin by means of a D-amino acid.
Inventors:
TAKINO YOSHINOBU (JP)
KARAKAWA SACHISE (JP)
OKURA FUMIE (JP)
IKEGAMI ERI (JP)
KARAKAWA SACHISE (JP)
OKURA FUMIE (JP)
IKEGAMI ERI (JP)
Application Number:
PCT/JP2018/009351
Publication Date:
September 27, 2018
Filing Date:
March 09, 2018
Export Citation:
Assignee:
AJINOMOTO KK (JP)
International Classes:
A61K8/44; A61Q1/04; A61Q1/12; A61Q1/14; A61Q17/04; A61Q19/02; A61Q19/10; G01N30/72; G01N30/88
Domestic Patent References:
| WO2013118887A1 | 2013-08-15 | |||
| WO2011040082A1 | 2011-04-07 |
Foreign References:
| JPH1149630A | 1999-02-23 | |||
| JP2008088113A | 2008-04-17 | |||
| JP2004315384A | 2004-11-11 | |||
| JP2005247738A | 2005-09-15 | |||
| JPH10158149A | 1998-06-16 | |||
| JP2012041285A | 2012-03-01 | |||
| JPH1149629A | 1999-02-23 | |||
| JP2013067592A | 2013-04-18 | |||
| JP2002060313A | 2002-02-26 | |||
| JP2009227660A | 2009-10-08 |
Other References:
TOJO, YOSUKE ET AL.: "Free D-amino acids as physiologically active molecules in skin tissue", FRAGRANCE JOURNAL, April 2016 (2016-04-01), pages 14 - 18, XP9516317
ASHIDA, YUTAKA ET AL.: "Presence of free D-amino acids in the skin and their physiological functions", BIO INDUSTRY, vol. 28, no. 2, 2011, pages 40 - 44, XP9516313
MIKAMI, NAOKO: "Amino acid and beatification", BIO INDUSTRY, vol. 25, no. 10, 2008, pages 21 - 25, XP9516314
JOURNAL OF JAPANESE COSMETIC SCIENCE SOCIETY, vol. 30, no. 4, 2006, pages 333 - 337
HAMASE KMORIKAWA AOHGUSU TLINDNER WZAITSU K: "Comprehensive analysis of branched aliphatic D-amino acids in mammals using an integrated multi-loop two-dimensional column-switching high-performance liquid chromatographic system combining reversed-phase and enantioselective columns", J CHROMATOGR A., vol. 1143, no. 1-2, 2 March 2007 (2007-03-02), pages 105 - 11, XP005879718, doi:10.1016/j.chroma.2006.12.078
GOGAMI YOKADA KOIKAWA T: "High-performance liquid chromatography analysis of naturally occurring D-amino acids in sake", J CHROMATOGR B ANALYT TECHNOL BIOMED LIFE SCI., vol. 879, no. 29, 1 November 2011 (2011-11-01), pages 3259 - 67, XP028324134, doi:10.1016/j.jchromb.2011.04.006
J. Z. MINS. HATANAKAH.F. YUT. HIGASHIS. INAGAKIT. TOYO'OKA: "Determination of DL-amino acids, derivatized with R(-)-4-(3-isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benz oxadiazole, in nail of diabetic patients by UPLC-ESI-TOF-MS", J. CHROMATOGR. B, vol. 879, 2011, pages 3220 - 3228
See also references of EP 3603611A4
ASHIDA, YUTAKA ET AL.: "Presence of free D-amino acids in the skin and their physiological functions", BIO INDUSTRY, vol. 28, no. 2, 2011, pages 40 - 44, XP9516313
MIKAMI, NAOKO: "Amino acid and beatification", BIO INDUSTRY, vol. 25, no. 10, 2008, pages 21 - 25, XP9516314
JOURNAL OF JAPANESE COSMETIC SCIENCE SOCIETY, vol. 30, no. 4, 2006, pages 333 - 337
HAMASE KMORIKAWA AOHGUSU TLINDNER WZAITSU K: "Comprehensive analysis of branched aliphatic D-amino acids in mammals using an integrated multi-loop two-dimensional column-switching high-performance liquid chromatographic system combining reversed-phase and enantioselective columns", J CHROMATOGR A., vol. 1143, no. 1-2, 2 March 2007 (2007-03-02), pages 105 - 11, XP005879718, doi:10.1016/j.chroma.2006.12.078
GOGAMI YOKADA KOIKAWA T: "High-performance liquid chromatography analysis of naturally occurring D-amino acids in sake", J CHROMATOGR B ANALYT TECHNOL BIOMED LIFE SCI., vol. 879, no. 29, 1 November 2011 (2011-11-01), pages 3259 - 67, XP028324134, doi:10.1016/j.jchromb.2011.04.006
J. Z. MINS. HATANAKAH.F. YUT. HIGASHIS. INAGAKIT. TOYO'OKA: "Determination of DL-amino acids, derivatized with R(-)-4-(3-isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benz oxadiazole, in nail of diabetic patients by UPLC-ESI-TOF-MS", J. CHROMATOGR. B, vol. 879, 2011, pages 3220 - 3228
See also references of EP 3603611A4
Attorney, Agent or Firm:
SAKAI INTERNATIONAL PATENT OFFICE (JP)
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