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Title:
SMAC MIMETICS USED AS IAP INHIBITORS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/091492
Kind Code:
A1
Abstract:
Disclosed are a class of SMAC mimetics used as IAP inhibitors, and in particular disclosed are compounds as shown in formula (I), isomers thereof, and pharmaceutically acceptable salts thereof. The IAP inhibitors are drugs for treating cancers, in particular breast cancer.

Inventors:
LIU, Yingchun (288 Futezhong Road, Pudong New Area, Shanghai 1, 200131, CN)
XU, Zhaobing (288 Futezhong Road, Pudong New Area, Shanghai 1, 200131, CN)
HU, Lihong (288 Futezhong Road, Pudong New Area, Shanghai 1, 200131, CN)
DING, Charles Z. (288 Futezhong Road, Pudong New Area, Shanghai 1, 200131, CN)
ZHU, Xingxun (288 Futezhong Road, Pudong New Area, Shanghai 1, 200131, CN)
HU, Guoping (288 Futezhong Road, Pudong New Area, Shanghai 1, 200131, CN)
LI, Jian (288 Futezhong Road, Pudong New Area, Shanghai 1, 200131, CN)
CHEN, Shuhui (288 Futezhong Road, Pudong New Area, Shanghai 1, 200131, CN)
Application Number:
CN2018/115256
Publication Date:
May 16, 2019
Filing Date:
November 13, 2018
Export Citation:
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Assignee:
MEDSHINE DISCOVERY INC. (Room 218, No.9 Gaoxin Road Gaoxin Development Distric, Nanjing Jiangsu 2, 210032, CN)
International Classes:
C07K5/06; A61K31/4045; A61P35/00; C07D403/06
Domestic Patent References:
WO2008014252A22008-01-31
Foreign References:
CN101951766A2011-01-19
CN101595121A2009-12-02
CN101605786A2009-12-16
CN101035802A2007-09-12
CN104159897A2014-11-19
CN101146803A2008-03-19
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (21st Floor Sfeco Mansion 681 Xiaomuqiao Road, Shanghai 2, 200032, CN)
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