Title:
SMALL BREAST EPITHELIAL MUCIN GENE PROMOTER
Document Type and Number:
WIPO Patent Application WO2006047883
Kind Code:
A3
Abstract:
The human small breast epithelial mucin gene promoter is analyzed and regions corresponding to a minimum promoter element for breast cell-specific expression, an enhancer and a negative regulatory element are identified.
Inventors:
HUBE FLORENT (CA)
MYAL YVONNE (CA)
LEYGUE ETIENNE (CA)
MYAL YVONNE (CA)
LEYGUE ETIENNE (CA)
Application Number:
PCT/CA2005/001697
Publication Date:
July 06, 2006
Filing Date:
November 08, 2005
Export Citation:
Assignee:
UNIV MANITOBA (CA)
HUBE FLORENT (CA)
MYAL YVONNE (CA)
LEYGUE ETIENNE (CA)
HUBE FLORENT (CA)
MYAL YVONNE (CA)
LEYGUE ETIENNE (CA)
International Classes:
C12N15/85
Other References:
DATABASE GENBANK [online] 27 September 2002 (2002-09-27), Database accession no. (AC117496)
HUBE F. ET AL.: "Human small breast epithelial mucin: the promise of a new breast tumor biomarker", DNA AND CELL BIOLOGY, vol. 23, no. 12, December 2004 (2004-12-01), pages 842 - 849
MIKSICEK R.J. ET AL.: "Identification of a novel breast and salivary gland-specific, mucin-like gene strongly expressed in normal and tumor human mammary epithelium", CANCER RESEARCH, vol. 62, no. 10, 15 May 2002 (2002-05-15), pages 2736 - 2740
KOVARIK A. ET AL.: "Two GC boxes (Sp1 sites) are involved in regulation of the activity of the epithelium-specific MUC1 promoter", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 30, July 1996 (1996-07-01), pages 18140 - 18147
COLPITTS T.L. ET AL.: "Identification and immunohistochemical characterization of a mucin-like glycoprotein expressed in early stage breast carcinoma", TUMOR BIOLOGY, vol. 23, no. 5, 2002, pages 263 - 278
HOUGHTON R.L. ET AL.: "Transcriptional complementarity in breast cancer: application to detection of circulating tumor cells", MOLECULAR DIAGNOSIS, vol. 6, no. 2, 2001, pages 79 - 91, XP008025755
HUBE F. ET AL.: "Human small breast epithelial mucin: the promise of a new breast tumor biomarker", DNA AND CELL BIOLOGY, vol. 23, no. 12, December 2004 (2004-12-01), pages 842 - 849
MIKSICEK R.J. ET AL.: "Identification of a novel breast and salivary gland-specific, mucin-like gene strongly expressed in normal and tumor human mammary epithelium", CANCER RESEARCH, vol. 62, no. 10, 15 May 2002 (2002-05-15), pages 2736 - 2740
KOVARIK A. ET AL.: "Two GC boxes (Sp1 sites) are involved in regulation of the activity of the epithelium-specific MUC1 promoter", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 30, July 1996 (1996-07-01), pages 18140 - 18147
COLPITTS T.L. ET AL.: "Identification and immunohistochemical characterization of a mucin-like glycoprotein expressed in early stage breast carcinoma", TUMOR BIOLOGY, vol. 23, no. 5, 2002, pages 263 - 278
HOUGHTON R.L. ET AL.: "Transcriptional complementarity in breast cancer: application to detection of circulating tumor cells", MOLECULAR DIAGNOSIS, vol. 6, no. 2, 2001, pages 79 - 91, XP008025755
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