Title:
SMALL MOLECULE COMPOUND HAVING PYRIMIDOTHIOPHENE STRUCTURE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/246371
Kind Code:
A1
Abstract:
The present application discloses a small molecule compound having a pyrimidothiophene structure, and a use thereof. By means of inhibiting activity of the cyclin-dependent kinase (CDK) family, the small molecule compound can block the cell cycle process and hinder the transcription of oncogenes, thereby inhibiting tumor cell proliferation and achieving the purpose of treating tumors.
Inventors:
FAN MENGYANG (CN)
MA DAWEI (CN)
DING KE (CN)
ZHANG HONGJIN (CN)
JIA SUYUN (CN)
MA DAWEI (CN)
DING KE (CN)
ZHANG HONGJIN (CN)
JIA SUYUN (CN)
Application Number:
PCT/CN2023/094038
Publication Date:
December 28, 2023
Filing Date:
May 12, 2023
Export Citation:
Assignee:
INST OF BASIC MEDICINE AND CANCER CHINESE ACADEMY OF SCIENCES (CN)
International Classes:
C07D519/00; A61K31/506; A61K31/519; A61P35/00; C07D333/00; C07D401/02; C07D403/02; C07D403/04; C07D403/12; C07D409/00; C07D495/02; C07F9/6561
Domestic Patent References:
| WO2022089444A1 | 2022-05-05 |
Foreign References:
| CN102712656A | 2012-10-03 | |||
| CN104292242A | 2015-01-21 | |||
| CN112661745A | 2021-04-16 | |||
| CN113226306A | 2021-08-06 | |||
| CN113557017A | 2021-10-26 | |||
| US20090118276A1 | 2009-05-07 | |||
| US20130012703A1 | 2013-01-10 | |||
| US20180153894A1 | 2018-06-07 |
Other References:
CHO HANNA, SHIN INJAE, YOON HOJONG, JEON EUNHYE, LEE JIWON, KIM YOUNGHOON, RYU SEONGSHICK, SONG CHIMAN, KWON NAM HOON, MOON YOUNGJ: "Identification of Thieno[3,2- d ]pyrimidine Derivatives as Dual Inhibitors of Focal Adhesion Kinase and FMS-like Tyrosine Kinase 3", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 64, no. 16, 26 August 2021 (2021-08-26), US , pages 11934 - 11957, XP093118556, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.1c00459
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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