THE SMALL MOLECULE INHIBITOR WHICH CAN INHIBIT THE AβPOLYPEPTIDE FIBROSIS OF ALZHEIMER'S DISEASE, THEIR PREPAREATION METHODS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF - SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Title:

THE SMALL MOLECULE INHIBITOR WHICH CAN INHIBIT THE AβPOLYPEPTIDE FIBROSIS OF ALZHEIMER'S DISEASE, THEIR PREPAREATION METHODS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2008/006276

Kind Code:

A1

Abstract:

A type of novel compounds having the symmetric structure of formula I, which can inhibit the congregation and fibrosis of β-amyloid protein, their pharmaceutically accepted salts, and preparation methods thereof. The pharmaceutical compositions containing these compounds or their pharmaceutically accepted salts, and the uses of these compounds or their pharmaceutically accepted salts or their pharmaceutical compositions for the manufacture of a medicament for the prevention or treatment of an Alzheimer's disease. The compounds or their pharmaceutically accepted salts discloses in present invention can inhibit the congregation and fibrosis of β-amyloid protein by combining with Aβ polypeptide. So they can be used to prevent or treat Alzheimer's diseases.

Inventors:

LIU, Dongxiang (No.555 Zuchongzhi Road, Zhangjiang Hi-Tech Park Pudong New District, Shanghai 3, 201203, CN)
刘东祥 (中国上海市浦东新区张江高科技园区祖冲之路555号, Shanghai 3, 201203, CN)
XU, Yechun (No.555 Zuchongzhi Road, Zhangjiang Hi-Tech Park Pudong New District, Shanghai 3, 201203, CN)
许叶春 (中国上海市浦东新区张江高科技园区祖冲之路555号, Shanghai 3, 201203, CN)
LIU, Hong (No.555 Zuchongzhi Road, Zhangjiang Hi-Tech Park Pudong New District, Shanghai 3, 201203, CN)
柳红 (中国上海市浦东新区张江高科技园区祖冲之路555号, Shanghai 3, 201203, CN)
ZHOU, Yu (No.555 Zuchongzhi Road, Zhangjiang Hi-Tech Park Pudong New District, Shanghai 3, 201203, CN)

Application Number:

CN2007/001518

Publication Date:

January 17, 2008

Filing Date:

May 09, 2007

Export Citation:

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Assignee:

SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (No.555 Zuchongzhi Road, Zhangjiang Hi-Tech Park Pudong New District, Shanghai 3, 201203, CN)
中国科学院上海药物研究所 (中国上海市浦东新区张江高科技园区祖冲之路555号, Shanghai 3, 201203, CN)
LIU, Dongxiang (No.555 Zuchongzhi Road, Zhangjiang Hi-Tech Park Pudong New District, Shanghai 3, 201203, CN)
刘东祥 (中国上海市浦东新区张江高科技园区祖冲之路555号, Shanghai 3, 201203, CN)
XU, Yechun (No.555 Zuchongzhi Road, Zhangjiang Hi-Tech Park Pudong New District, Shanghai 3, 201203, CN)
许叶春 (中国上海市浦东新区张江高科技园区祖冲之路555号, Shanghai 3, 201203, CN)
LIU, Hong (No.555 Zuchongzhi Road, Zhangjiang Hi-Tech Park Pudong New District, Shanghai 3, 201203, CN)
柳红 (中国上海市浦东新区张江高科技园区祖冲之路555号, Shanghai 3, 201203, CN)

International Classes:

C07C39/06; A61K31/085; A61K31/10; A61K31/135; A61P25/28; C07C15/16; C07C43/23; C07C69/80; C07C319/14; C07D295/02; C07D295/03; C07D307/28; C07C39/00; A61K31/075; A61K31/095; A61K31/135; A61P25/00; C07C15/00; C07C43/00; C07C69/00; C07C319/00; C07D295/00; C07D307/00

Attorney, Agent or Firm:

KINGSOUND & PARTNERS (11/F, Block B Kingsound International Center, 116 Zizhuyuan Road, Haidian District, Beijing 7, 100097, CN)

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