Title:
SMALL MOLECULE INHIBITORS OF CASPASES
Document Type and Number:
WIPO Patent Application WO2003024955
Kind Code:
A3
Abstract:
The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein A, B, D, E, G, J, n, and R1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof as caspase inhibitors and for the treatment of disorders caused by excessive apoptotic activity.
Inventors:
CHOONG INGRID (US)
BURDETT MATTHEW (US)
DELANO WARREN (US)
ERLANSON DANIEL A (US)
LEE DENNIS (US)
LEW WILLARD (US)
BURDETT MATTHEW (US)
DELANO WARREN (US)
ERLANSON DANIEL A (US)
LEE DENNIS (US)
LEW WILLARD (US)
Application Number:
PCT/US2002/029536
Publication Date:
August 14, 2003
Filing Date:
September 17, 2002
Export Citation:
Assignee:
SUNESIS PHARMACEUTICALS INC (US)
CHOONG INGRID (US)
BURDETT MATTHEW (US)
DELANO WARREN (US)
ERLANSON DANIEL A (US)
LEE DENNIS (US)
LEW WILLARD (US)
CHOONG INGRID (US)
BURDETT MATTHEW (US)
DELANO WARREN (US)
ERLANSON DANIEL A (US)
LEE DENNIS (US)
LEW WILLARD (US)
International Classes:
A61P25/28; C07C237/42; C07C275/24; C07C275/42; C07C311/06; C07C311/19; C07C311/29; C07C317/46; C07C317/50; C07C323/59; C07D213/82; C07D215/36; C07D233/84; C07D239/38; C07D241/24; C07D257/04; C07D261/18; C07D261/20; C07D263/58; C07D277/56; C07D285/08; C07D307/68; C07D311/22; C07D319/18; C07D333/18; C07D333/38; C07D401/12; C07D403/12; C07D409/12; C07D413/12; C07D417/04; (IPC1-7): C07D333/38; A61K31/18; A61K31/34; A61K31/38; A61K31/40; A61K31/41; A61K31/415; A61K31/42; A61K31/425; A61K31/44; A61P25/28; C07C311/18; C07D213/82; C07D215/36; C07D233/84; C07D239/38; C07D241/24; C07D257/04; C07D261/18; C07D261/20; C07D263/58; C07D277/56; C07D285/08; C07D307/68; C07D311/22; C07D319/18; C07D333/18; C07D401/12; C07D403/12; C07D409/12; C07D413/12; C07D417/04; C07D417/12
Domestic Patent References:
| WO2001027085A1 | 2001-04-19 | |||
| WO2001021599A1 | 2001-03-29 | |||
| WO2001010383A2 | 2001-02-15 | |||
| WO1998016502A1 | 1998-04-23 |
Other References:
R.V. TALANIAN ET AL.: "Caspases as targets for anti-inflammatory and anti-apoptotic drug discovery", J. MED. CHEM., vol. 43, no. 18, August 2000 (2000-08-01), pages 3351 - 3371, XP002223863
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