SMALL MOLECULE INHIBITORS OF THE CRL4 UBIQUITIN LIGASE

Title:

SMALL MOLECULE INHIBITORS OF THE CRL4 UBIQUITIN LIGASE

Document Type and Number:

WIPO Patent Application WO/2023/173136

Kind Code:

A3

Abstract:

Compounds of formula (I), compounds of formula (II), and compounds of formula (III) are disclosed. Also disclosed are compounds, compositions, and methods to inhibit CUL4A expression or activity, CUL4B expression or activity, and/or DDB1 expression or activity for the treatment or prevention of cancer, DNA damage, or related conditions. In some aspects, the interaction between CUL4A and/or CUL4B and the beta-propeller B of DDB1 is disrupted with the compounds, compositions, or methods.

Inventors:

ZHOU PENGBO (US)
YANG CHENYI (US)
SHI LEI (US)

Application Number:

PCT/US2023/064232

Publication Date:

October 26, 2023

Filing Date:

March 13, 2023

Export Citation:

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Assignee:

UNIV CORNELL (US)

International Classes:

C07D471/14; A61K31/404; A61P35/00; A61P43/00

Foreign References:

US20150196546A1	2015-07-16
US20220041576A1	2022-02-10

Other References:

DATABASE PUBCHEM SUBSTANCE ANONYMOUS : "SID 396112442", XP093104413, retrieved from PUBCHEM

Attorney, Agent or Firm:

GASE, John L. (US)

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