Title:
SMALL PEPTIDE INHIBITORS OF β-AMYLOID TOXICITY
Document Type and Number:
WIPO Patent Application WO/2014/184596
Kind Code:
A3
Abstract:
The invention relates to peptides and peptidomimetics useful for reducing the neurotoxicity of amyloid peptide aggregates or prion-like (prionoid) protein aggregates, the invention further relates to pharmaceutical compositions containing said peptides and/or peptidomimetics, to the use of said peptides and/or peptidomimetics in the manufacture of medicines useful for the prophylaxis or treatment of diseases that can be cured by protection against the detrimental effect of Αβ-peptides /abnormal Αβ aggregation leading to amyloid plaque formation, and it relates to the use of said peptides and/or peptidomimetics in the prophylaxis or treatment of the above mentioned diseases. The invention aimed at developing treatments of neurodegenerative diseases, particularly Alzheimer's disease (AD), during which accumulation of misfolded and/or aggregated proteins occurs.
Inventors:
FÜLÖP LÍVIA (HU)
PENKE BOTOND (HU)
ZARÁNDI MÁRTA (HU)
BOZSÓ ZSOLT (HU)
VIRÓK DEZSÖ (HU)
JANÁKY TAMÁS (HU)
VERDIER YANN (HU)
DATKI ZSOLT (HU)
SZEGEDI VIKTOR (HU)
BUSA-FEKETE RÓBERT (FR)
SOÓS KATALIN (HU)
KASZA ÁGNES (HU)
KOCSOR ANDRÁS (HU)
BORBÉLY ERMÖKE (HU)
PENKE BOTOND (HU)
ZARÁNDI MÁRTA (HU)
BOZSÓ ZSOLT (HU)
VIRÓK DEZSÖ (HU)
JANÁKY TAMÁS (HU)
VERDIER YANN (HU)
DATKI ZSOLT (HU)
SZEGEDI VIKTOR (HU)
BUSA-FEKETE RÓBERT (FR)
SOÓS KATALIN (HU)
KASZA ÁGNES (HU)
KOCSOR ANDRÁS (HU)
BORBÉLY ERMÖKE (HU)
Application Number:
PCT/HU2014/000042
Publication Date:
April 16, 2015
Filing Date:
May 08, 2014
Export Citation:
Assignee:
UNIV SZEGEDI (HU)
International Classes:
C07K5/072; C07K5/093; C07K5/103; C07K7/06
Domestic Patent References:
| WO2001010457A2 | 2001-02-15 | |||
| WO2006087550A2 | 2006-08-24 | |||
| WO2008050133A2 | 2008-05-02 |
Other References:
KOKKONI NICOLETA ET AL: "N-methylated peptide inhibitors of beta-amyloid aggregation and toxicity. Optimization of the inhibitor structure", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 45, no. 32, 1 August 2006 (2006-08-01), pages 9906 - 9918, XP002419875, ISSN: 0006-2960, DOI: 10.1021/BI060837S
"AGN-PC-0G4V3U - PubChem", 23 October 2012 (2012-10-23), XP055139054, Retrieved from the Internet [retrieved on 20140909]
"AGN-PC-0G4V3U - PubChem", 23 October 2012 (2012-10-23), XP055139054, Retrieved from the Internet
Attorney, Agent or Firm:
KOVÁRI, Zoltán (Attila ut 125, Budapest, HU)
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