Title:
SMALL PEPTIDE AND USE THEREOF IN MUCOSAL REPAIR
Document Type and Number:
WIPO Patent Application WO/2024/067535
Kind Code:
A1
Abstract:
Provided are a small peptide and a use thereof in mucosal repair. The small peptide is selected from a basic small peptide having a sequence as shown in SEQ ID NO. 1 or SEQ ID NO. 2 or a lead small peptide containing the basic small peptide, wherein the lead small peptide can be enzymolyzed under the effect of a digestive enzyme in an animal body to obtain the basic small peptide. The small peptide has a mucosal repair effect, and after being replicated in large quantities by a Fmoc solid-phase synthesis method, the small peptide is verified by means of animal experiments to have properties related to mucosal repair; moreover, toxicology experiments prove that the small peptide has no hepatotoxicity or nephrotoxicity, and has high safety.
Inventors:
ZHANG XITONG (CN)
YIN XIAOJIAN (CN)
YIN XIAOJIAN (CN)
Application Number:
PCT/CN2023/121316
Publication Date:
April 04, 2024
Filing Date:
September 26, 2023
Export Citation:
Assignee:
FORREST BIO PHARM SHENZHEN CO LTD (CN)
International Classes:
C07K7/06; A61K38/02; A61K38/03; A61P1/04; A61P15/00; C07K1/06
Domestic Patent References:
| WO2013092851A1 | 2013-06-27 | |||
| WO2015113481A1 | 2015-08-06 |
Foreign References:
| CN110128506A | 2019-08-16 | |||
| CN102917724A | 2013-02-06 | |||
| CN114652812A | 2022-06-24 |
Other References:
NAIXIN LIU: "Discovery of a novel rice-derived peptide with significant anti-gout potency", FOOD & FUNCTION, R S C PUBLICATIONS, GB, vol. 11, no. 12, 17 December 2020 (2020-12-17), GB , pages 10542 - 10553, XP093152138, ISSN: 2042-6496, DOI: 10.1039/D0FO01774D
CHRISTINA NASADYUK: "Gastroprotective Oligopeptides", GASTROENTEROLOGY & HEPATOLOGY: OPEN ACCESS, vol. 3, no. 1, 6 November 2015 (2015-11-06), XP093152148, ISSN: 2373-6372, DOI: 10.15406/ghoa.2015.03.00068
CHRISTINA NASADYUK: "Gastroprotective Oligopeptides", GASTROENTEROLOGY & HEPATOLOGY: OPEN ACCESS, vol. 3, no. 1, 6 November 2015 (2015-11-06), XP093152148, ISSN: 2373-6372, DOI: 10.15406/ghoa.2015.03.00068
Attorney, Agent or Firm:
GUANGZHOU SINO PATENT & TRADEMARK AGENT CO., LTD. (CN)
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