Title:
SMART INSULIN DRUG DELIVERY SYSTEM RESPONDING TO OUTSIDE
Document Type and Number:
WIPO Patent Application WO/2023/017925
Kind Code:
A1
Abstract:
The present invention relates to an insulin drug delivery system that is self-regulated by external stimuli such as glucose concentration, pH, temperature, or wavelength and comprises insulin and a polyhedral oligomeric silsesquioxane (POSS) functionalized with aminophenylboronic acid (APBA). The insulin drug delivery system, according to the present invention, is advantageous in that drug release can be easily controlled without the difficulty and inconvenience of a biosensor or blood sugar check.
Inventors:
KIM KYU OH (KR)
Application Number:
PCT/KR2021/020297
Publication Date:
February 16, 2023
Filing Date:
December 30, 2021
Export Citation:
Assignee:
UNIV DANKOOK IACF (KR)
International Classes:
A61K9/107; A61K38/28; A61K47/24; A61K47/34; A61P3/10
Foreign References:
| KR20200069010A | 2020-06-16 | |||
| JP2015537078A | 2015-12-24 | |||
| KR20200122255A | 2020-10-27 | |||
| KR101208568B1 | 2012-12-06 |
Other References:
KIM YEON JU; KIM KYU OH.; LEE JUNG JIN: "d-Glucose recognition based on phenylboronic acid-functionalized polyoligomeric silsesquioxane fluorescent probe", MATERIALS SCIENCE AND ENGINEERING C, ELSEVIER SCIENCE S.A., CH, vol. 95, 30 October 2018 (2018-10-30), CH , pages 286 - 291, XP085560084, ISSN: 0928-4931, DOI: 10.1016/j.msec.2018.10.090
KIM WON JUNG, KWON YONG-JIN, CHO CHUNG-HYUN, YE SANG-KYU, KIM KYU OH: "Insulin smart drug delivery nanoparticles of aminophenylboronic acid–POSS molecule at neutral pH", SCIENTIFIC REPORTS, vol. 11, no. 1, XP093034689, DOI: 10.1038/s41598-021-01216-3
KIM WON JUNG, KWON YONG-JIN, CHO CHUNG-HYUN, YE SANG-KYU, KIM KYU OH: "Insulin smart drug delivery nanoparticles of aminophenylboronic acid–POSS molecule at neutral pH", SCIENTIFIC REPORTS, vol. 11, no. 1, XP093034689, DOI: 10.1038/s41598-021-01216-3
Attorney, Agent or Firm:
MUHANN PATENT & LAW FIRM (KR)
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