Title:
SMART POLYMERIC NANOPARTICLES WHICH OVERCOME MULTIDRUG RESISTANCE TO CANCER CHEMOTHERAPEUTICS AND TREATMENT-RELATED SYSTEMIC TOXICITY
Document Type and Number:
WIPO Patent Application WO/2012/078831
Kind Code:
A3
Abstract:
Polymeric nanoparticles with a hydrophobic core that encapsulates curcumin and a hydrophilic shell with one or more chemotherapeutic agents (e.g., doxorubicin) associated with the shell surface are formed from N-isopropylacryl amide (NEPAAM), acrylic acid (AA), and at least one vinyl monomer selected from the group consisting of vinyl acetate, 4-vinyl benzoic acid, methylmethacrylate, vinylmethacrylate, N-vinylpyrrolidone, N-vinyl piperidone, N-vinyl caprolacum, N-vinyl carbazole, and styrene, where the ΝΓΡΑΑΜ, the AA, and the vinyl monomer are present at molar ratios of 50-70:10-30: 10-30 for NIPAAM:AA:vmyl monomer. These nanoparticles effectively overcome multidrug resistance and ameliorate cardiomyopathy in vivo.
Inventors:
MAITRA ANIRBAN (US)
PRAMANIK DIPANKAR (IN)
PRAMANIK DIPANKAR (IN)
Application Number:
PCT/US2011/063870
Publication Date:
November 15, 2012
Filing Date:
December 08, 2011
Export Citation:
Assignee:
UNIV JOHNS HOPKINS (US)
MAITRA ANIRBAN (US)
PRAMANIK DIPANKAR (IN)
MAITRA ANIRBAN (US)
PRAMANIK DIPANKAR (IN)
International Classes:
A61K47/48; A61K9/127; A61K31/704; A61K31/7042; A61P35/00; C08F20/06; C08F20/56
Foreign References:
| US20080107749A1 | 2008-05-08 | |||
| US20080253961A1 | 2008-10-16 | |||
| US20060257493A1 | 2006-11-16 | |||
| US20090157042A1 | 2009-06-18 |
Other References:
See also references of EP 2648760A4
Attorney, Agent or Firm:
WHITHAM, Michael, E. et al. (Curtis Christofferson & Cook, P.C.,11491 Sunset Hills Road, Suite 34, Reston VA, US)
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