Title:
SMYD2 AS A TARGET GENE FOR CANCER THERAPY AND DIAGNOSIS
Document Type and Number:
WIPO Patent Application WO/2013/080400
Kind Code:
A1
Abstract:
The present invention arises from the discovery that the SMYD2 gene is both specifically over-expressed in cancer and involved in cancer cell survival. The present invention features methods for detecting or diagnosing the presence of or predisposition for developing cancer, using the SMYD2 gene as a diagnostic marker. The present invention further provides methods of screening for therapeutic substances useful in either or both of the treatment and prevention of cancer.
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Inventors:
HAMAMOTO RYUJI (JP)
NAKAMURA YUSUKE (JP)
TSUNODA TAKUYA (JP)
NAKAMURA YUSUKE (JP)
TSUNODA TAKUYA (JP)
Application Number:
PCT/JP2012/004232
Publication Date:
June 06, 2013
Filing Date:
June 29, 2012
Export Citation:
Assignee:
ONCOTHERAPY SCIENCE INC (JP)
HAMAMOTO RYUJI (JP)
NAKAMURA YUSUKE (JP)
TSUNODA TAKUYA (JP)
HAMAMOTO RYUJI (JP)
NAKAMURA YUSUKE (JP)
TSUNODA TAKUYA (JP)
International Classes:
C12N15/09; C12Q1/68; G01N33/15; G01N33/574
Domestic Patent References:
| WO2005071102A2 | 2005-08-04 | |||
| WO2003027143A2 | 2003-04-03 |
Foreign References:
| JP2010220577A | 2010-10-07 |
Other References:
CHO, H.S. ET AL.: "RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation", NEOPLASIA, vol. 14, no. 6, June 2012 (2012-06-01), pages 476 - 486, XP055071015
KOMATSU, S. ET AL.: "Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma", CARCINOGENESIS, vol. 30, no. 7, July 2009 (2009-07-01), pages 1139 - 1146, XP002603939
BARROS FILHO, M. C. ET AL.: "Gene trio signatures as molecular markers to predict response to doxorubicin cyclophosphamide neoadjuvant chemotherapy in breast cancer patients", BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, vol. 43, no. 12, December 2010 (2010-12-01), pages 1225 - 1231, XP055071016
ABU-FARHA, M. ET AL.: "Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2", JOURNAL OF MOLECULAR CELL BIOLOGY, vol. 3, no. 5, October 2011 (2011-10-01), pages 301 - 308, XP055071017
BROWN, M.A. ET AL.: "Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex", MOLECULAR CANCER, vol. 5, no. 1, 28 June 2006 (2006-06-28), pages 1 - 11, XP002616236
ABU-FARHA, M. ET AL.: "The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase", MOLECULAR & CELLULAR PROTEOMICS, vol. 7, no. 3, March 2008 (2008-03-01), pages 560 - 572, XP055071019
SADDIC, L.A. ET AL.: "Methylation of the retinoblastoma tumor suppressor by SMYD2", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, no. 48, 26 November 2010 (2010-11-26), pages 37733 - 37740, XP055071020
HUANG, J. ET AL.: "Repression of p53 activity by Smyd2-mediated methylation", NATURE, vol. 444, no. 7119, 30 November 2006 (2006-11-30), pages 629 - 632, XP002616235
TREPEL, J.; MOLLAPOUR, M.; GIACCONE, G.; NECKERS, L., NAT REV CANCER, vol. 10, 2010, pages 537 - 549
WANDINGER, S.K.; RICHTER, K.; BUCHNER, J., J BIOL CHEM, vol. 283, 2008, pages 18473 - 18477
PRATT, W.B.; TOFT, D.O., EXP BIOL MED (MAYWOOD, vol. 228, 2003, pages 111 - 133
WHITESELL, L.; LINDQUIST, S.L., NAT REV CANCER, vol. 5, 2005, pages 761 - 772
OGISO, H. ET AL., BIOCHEMISTRY, vol. 43, 2004, pages 15510 - 15519
DUVAL, M.; LE BOEUF, F.; HUOT, J.; GRATTON, J.P, MOL BIOL CELL, vol. 18, 2007, pages 4659 - 4668
SCROGGINS, B.T. ET AL., MOL CELL, vol. 25, 2007, pages 151 - 159
KOVACS, JJ. ET AL., MOL CELL, vol. 18, 2005, pages 601 - 607
RETZLAFF, M. ET AL., EMBO REP, vol. 10, 2009, pages 1147 - 1153
MARTINEZ-RUIZ, A. ET AL., PROC NATL ACAD SEI U S A, vol. 102, 2005, pages 8525 - 8530
HAMAMOTO R ET AL., NAT CELL BIOL, vol. 6, 2004, pages 731 - 740
TAKAWA, M. ET AL., CANCER SEI, 2011
YOSHIMATSU, M. ET AL., INT J CANCER, vol. 128, 2011, pages 562 - 573
SCHNEIDER, R.; BANNISTER, A.J.; KOUZARIDES, T., TRENDS BIOCHEM SEI, vol. 27, 2002, pages 396 - 402
SPARMANN, A.; VAN LOHUIZEN, M., NAT REV CANCER, vol. 6, 2006, pages 846 - 856
BROWN, M.A.; SIMS, R.J.; GOTTLIEB, P.D.; TUCKER, P.W., MOL CANCER, vol. 5, 2006, pages 26
HUANG, J. ET AL., NATURE, vol. 444, 2006, pages 629 - 632
SADDIC, L.A. ET AL., J BIOL CHEM, vol. 285, 2010, pages 37733 - 37740
KAWAMURA, S.; YOSHIGAI, E.; KUHARA, S.; TASHIRO, K., CYTOTECHNOLOGY, vol. 57, 2008, pages 161 - 168
DIEHL, F. ET AL., PLOS ONE, vol. 5, 2010, pages E9748
GOTTLIEB, P.D. ET AL., NAT GENET, vol. 31, 2002, pages 25 - 32
BURKHART, DL. ET AL., NAT REV CANCER, vol. 8, 2008, pages 671 - 682
KNUDSEN, ES ET AL., NAT REV CANCER, vol. 8, 2008, pages 714 - 724
WEINBERG, RA. ET AL., CELL, vol. 81, 1995, pages 323 - 330
SHERRCJ, SCIENCE, vol. 274, 1996, pages 1672 - 1677
SHERR, CJ. ET AL., CANCER CELL, vol. 2, 2002, pages 103 - 112
CHAN, HM. ET AL., NAT CELL BIOL, vol. 3, 2001, pages 667 - 674
NGUYEN, DX. ET AL., EMBO J, vol. 23, 2004, pages 1609 - 1618
PICKARD, A. ET AL., J CELL SCI, vol. 123, 2010, pages 3718 - 3726
ANDREWD RERGUSON ET AL.: "Structure", vol. 19, 2011, CURRENT BIOLOGY LTD., pages: 1262 - 1273
See also references of EP 2785870A4
KOMATSU, S. ET AL.: "Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma", CARCINOGENESIS, vol. 30, no. 7, July 2009 (2009-07-01), pages 1139 - 1146, XP002603939
BARROS FILHO, M. C. ET AL.: "Gene trio signatures as molecular markers to predict response to doxorubicin cyclophosphamide neoadjuvant chemotherapy in breast cancer patients", BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, vol. 43, no. 12, December 2010 (2010-12-01), pages 1225 - 1231, XP055071016
ABU-FARHA, M. ET AL.: "Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2", JOURNAL OF MOLECULAR CELL BIOLOGY, vol. 3, no. 5, October 2011 (2011-10-01), pages 301 - 308, XP055071017
BROWN, M.A. ET AL.: "Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex", MOLECULAR CANCER, vol. 5, no. 1, 28 June 2006 (2006-06-28), pages 1 - 11, XP002616236
ABU-FARHA, M. ET AL.: "The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase", MOLECULAR & CELLULAR PROTEOMICS, vol. 7, no. 3, March 2008 (2008-03-01), pages 560 - 572, XP055071019
SADDIC, L.A. ET AL.: "Methylation of the retinoblastoma tumor suppressor by SMYD2", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, no. 48, 26 November 2010 (2010-11-26), pages 37733 - 37740, XP055071020
HUANG, J. ET AL.: "Repression of p53 activity by Smyd2-mediated methylation", NATURE, vol. 444, no. 7119, 30 November 2006 (2006-11-30), pages 629 - 632, XP002616235
TREPEL, J.; MOLLAPOUR, M.; GIACCONE, G.; NECKERS, L., NAT REV CANCER, vol. 10, 2010, pages 537 - 549
WANDINGER, S.K.; RICHTER, K.; BUCHNER, J., J BIOL CHEM, vol. 283, 2008, pages 18473 - 18477
PRATT, W.B.; TOFT, D.O., EXP BIOL MED (MAYWOOD, vol. 228, 2003, pages 111 - 133
WHITESELL, L.; LINDQUIST, S.L., NAT REV CANCER, vol. 5, 2005, pages 761 - 772
OGISO, H. ET AL., BIOCHEMISTRY, vol. 43, 2004, pages 15510 - 15519
DUVAL, M.; LE BOEUF, F.; HUOT, J.; GRATTON, J.P, MOL BIOL CELL, vol. 18, 2007, pages 4659 - 4668
SCROGGINS, B.T. ET AL., MOL CELL, vol. 25, 2007, pages 151 - 159
KOVACS, JJ. ET AL., MOL CELL, vol. 18, 2005, pages 601 - 607
RETZLAFF, M. ET AL., EMBO REP, vol. 10, 2009, pages 1147 - 1153
MARTINEZ-RUIZ, A. ET AL., PROC NATL ACAD SEI U S A, vol. 102, 2005, pages 8525 - 8530
HAMAMOTO R ET AL., NAT CELL BIOL, vol. 6, 2004, pages 731 - 740
TAKAWA, M. ET AL., CANCER SEI, 2011
YOSHIMATSU, M. ET AL., INT J CANCER, vol. 128, 2011, pages 562 - 573
SCHNEIDER, R.; BANNISTER, A.J.; KOUZARIDES, T., TRENDS BIOCHEM SEI, vol. 27, 2002, pages 396 - 402
SPARMANN, A.; VAN LOHUIZEN, M., NAT REV CANCER, vol. 6, 2006, pages 846 - 856
BROWN, M.A.; SIMS, R.J.; GOTTLIEB, P.D.; TUCKER, P.W., MOL CANCER, vol. 5, 2006, pages 26
HUANG, J. ET AL., NATURE, vol. 444, 2006, pages 629 - 632
SADDIC, L.A. ET AL., J BIOL CHEM, vol. 285, 2010, pages 37733 - 37740
KAWAMURA, S.; YOSHIGAI, E.; KUHARA, S.; TASHIRO, K., CYTOTECHNOLOGY, vol. 57, 2008, pages 161 - 168
DIEHL, F. ET AL., PLOS ONE, vol. 5, 2010, pages E9748
GOTTLIEB, P.D. ET AL., NAT GENET, vol. 31, 2002, pages 25 - 32
BURKHART, DL. ET AL., NAT REV CANCER, vol. 8, 2008, pages 671 - 682
KNUDSEN, ES ET AL., NAT REV CANCER, vol. 8, 2008, pages 714 - 724
WEINBERG, RA. ET AL., CELL, vol. 81, 1995, pages 323 - 330
SHERRCJ, SCIENCE, vol. 274, 1996, pages 1672 - 1677
SHERR, CJ. ET AL., CANCER CELL, vol. 2, 2002, pages 103 - 112
CHAN, HM. ET AL., NAT CELL BIOL, vol. 3, 2001, pages 667 - 674
NGUYEN, DX. ET AL., EMBO J, vol. 23, 2004, pages 1609 - 1618
PICKARD, A. ET AL., J CELL SCI, vol. 123, 2010, pages 3718 - 3726
ANDREWD RERGUSON ET AL.: "Structure", vol. 19, 2011, CURRENT BIOLOGY LTD., pages: 1262 - 1273
See also references of EP 2785870A4
Attorney, Agent or Firm:
SHIMIZU, Hatsushi et al. (1-1-1 Oroshi-machi, Tsuchiura-sh, Ibaraki 47, JP)
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