Title:
SNP FOR PREDICTING THE SENSITIVITY TO ANTICANCER TARGETED THERAPEUTIC FORMULATION
Document Type and Number:
WIPO Patent Application WO/2011/159004
Kind Code:
A1
Abstract:
The present invention relates to a single nucleotide polymorphism (SNP) for predicting the sensitivity to an anticancer targeted therapeutic formulation, a polynucleotide containing the same, and a method for predicting the sensitivity to an anticancer targeted therapeutic formulation. According to the present invention, it is possible to predict the sensitivity of each individual to a certain anticancer targeted therapeutic formulation, using a small amount of a sample taken from a patient and thus to select a most suitable targeted therapeutic formulation over the entire duration of treatment for the patient.
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Inventors:
KIM JIN CHEON (KR)
KIM YONG SUNG (KR)
KIM SEON YOUNG (KR)
CHO DONG HYUNG (KR)
KIM YONG SUNG (KR)
KIM SEON YOUNG (KR)
CHO DONG HYUNG (KR)
Application Number:
PCT/KR2010/008734
Publication Date:
December 22, 2011
Filing Date:
December 08, 2010
Export Citation:
Assignee:
ASAN FOUNDATION (KR)
KOREA RES INST OF BIOSCIENCE (KR)
KIM JIN CHEON (KR)
KIM YONG SUNG (KR)
KIM SEON YOUNG (KR)
CHO DONG HYUNG (KR)
KOREA RES INST OF BIOSCIENCE (KR)
KIM JIN CHEON (KR)
KIM YONG SUNG (KR)
KIM SEON YOUNG (KR)
CHO DONG HYUNG (KR)
International Classes:
C12N15/11; C12Q1/68; G01N33/15
Foreign References:
| KR20090130540A | 2009-12-24 | |||
| KR20080115296A | 2008-11-19 |
Other References:
GAMAZON, E.R. ET AL.: "Chemotherapeutic drug susceptibility associated SNPs are enriched in expression quantitative trait loci", PROC. NATL. ACAD. SCI. USA, vol. 107, no. 20, 18 May 2010 (2010-05-18), pages 9287 - 9292
STOCCO, G. ET AL.: "Genetic polymorphism of inosine-triphosphate-pyrophosphatase influences mercaptopurine metabolism and toxicity during treatment of acute lymphoblastic leukemia individualized for thiopurine-S-methyl-transferase status", EXPERT OPIN. DRUG SAF., vol. 9, no. 1, January 2010 (2010-01-01), pages 23 - 37
DAVIDSEN, M.L. ET AL.: "Pharmacogenetics influence treatment efficacy in childhood acute lymphoblastic leukemia", J. PEDIATR. HEMATOL. ONCOL., vol. 30, no. 11, November 2008 (2008-11-01), pages 831 - 849
HASEGAWA, T. ET AL.: "Analysis of single nucleotide polymorphisms in uridine/cytidine kinase gene encoding metabolic enzyme of 3'-ethynylcytidine", NUCLEIC ACIDS RES., vol. 2, 2002, pages 237 - 238
HUANG; RATAIN, CA CANCER J CLIN, vol. 59, 2009, pages 42 - 55
GE D; ZHANG K; NEED AC ET AL.: "Japanese database with linkage disequilibrium(LD) block; WGAViewer", GENOMERES, vol. 18, 2008, pages 640 - 643
THERASSE ET AL., J NATL CANCER INST, vol. 92, 2000, pages 205 - 16
STOCCO, G. ET AL.: "Genetic polymorphism of inosine-triphosphate-pyrophosphatase influences mercaptopurine metabolism and toxicity during treatment of acute lymphoblastic leukemia individualized for thiopurine-S-methyl-transferase status", EXPERT OPIN. DRUG SAF., vol. 9, no. 1, January 2010 (2010-01-01), pages 23 - 37
DAVIDSEN, M.L. ET AL.: "Pharmacogenetics influence treatment efficacy in childhood acute lymphoblastic leukemia", J. PEDIATR. HEMATOL. ONCOL., vol. 30, no. 11, November 2008 (2008-11-01), pages 831 - 849
HASEGAWA, T. ET AL.: "Analysis of single nucleotide polymorphisms in uridine/cytidine kinase gene encoding metabolic enzyme of 3'-ethynylcytidine", NUCLEIC ACIDS RES., vol. 2, 2002, pages 237 - 238
HUANG; RATAIN, CA CANCER J CLIN, vol. 59, 2009, pages 42 - 55
GE D; ZHANG K; NEED AC ET AL.: "Japanese database with linkage disequilibrium(LD) block; WGAViewer", GENOMERES, vol. 18, 2008, pages 640 - 643
THERASSE ET AL., J NATL CANCER INST, vol. 92, 2000, pages 205 - 16
Attorney, Agent or Firm:
KIM, SOON WOONG (KR)
κΉμμ (KR)
κΉμμ (KR)
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