SODIUM CARBOXYMETHYL STARCH AND INJECTION THEREOF

WIPO Patent Application WO/2023/123994

A1

The present invention relates to a sodium carboxymethyl starch and an injection thereof, a preparation method for a sodium carboxymethyl starch and an injection thereof, and a use for preparing blood substitutes. The sodium carboxymethyl starch described in the present invention is a sodium carboxymethyl starch having a molecular weight of 151,000-420,000, a conductivity meter substitution degree of 0.1-1.1, a specific rotation of 185-198, and an intrinsic viscosity of 20-45, and can be used to prepare blood substitutes. The preparation method for the sodium carboxymethyl starch and the sodium carboxymethyl starch injection in the present invention is simple and convenient, economical and suitable for industrial production.

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SHI WEIQUN (CN)

PCT/CN2022/104064

July 06, 2023

July 06, 2022

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SHI WEIQUN (CN)

A61K9/08; A61K31/718; A61K47/02; A61P7/08

CN114053422A	2022-02-18
CN101081229A	2007-12-05
US20190381217A1	2019-12-19

YOU, GUOXING ET AL.: "Effect of Sodium Carboxymethyl Starch on Erythrocyte Rheology and Oxygen Carrying Function", JOURNAL OF INTERNATIONAL PHARMACEUTICAL RESEARCH, vol. 46, no. 10, 31 October 2019 (2019-10-31), XP009546995, ISSN: 1674-0440
CHEN, CHEN ET AL.: "Study on the Effectiveness and Safety of Sodium Carboxymethyl Starch Solution as an Endoscopic Submucosal Injection in Porcine Endoscopic Submucosal Dissection", ZHONGHUA XIAOHUA ZAZHI, ZHONGHUA YIXUEHUI, SHANGHAI FENHUI, CHINA, vol. 40, no. 7, 31 July 2020 (2020-07-31), China , pages 487 - 490, XP009547516, ISSN: 0254-1432
PLASMA SUBSITUTE JOINT RESEARCH GROUP: "CARBOXYMETHYLAMYLOSE AS A NEW PLASMA SUBSTITUTE - Ⅰ. CHEMICAL PROPERTIES", ACTA CHIMICA SINICA, vol. 36, no. 1, 1 February 1978 (1978-02-01), pages 49 - 76, XP093076288

SHANGHAI HENGHUI INTELLECTUAL PROPERTY AGENCY (CN)

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